SCHEMBL1223474

SCHEMBL1223474

NNC(=O)NCCc1ccc(Cl)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 7/20 0.68
IDO1 P14902 1/20 0.59
CYP1A2 P05177 3/20 0.58
CYP2D6 P10635 3/20 0.58
CYP2C19 P33261 3/20 0.58
NPC1 O15118 2/20 0.58
RAB9A P51151 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
MAPT P10636 2/20 0.57
MEN1 O00255 1/20 0.57
LMNA P02545 1/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2C9 P11712 1/20 0.57
HTT P42858 1/20 0.57
KMT2A Q03164 1/20 0.57
EPHX1 P07099 1/20 0.57
L3MBTL1 Q9Y468 2/20 0.57
KDM4E B2RXH2 2/20 0.57
CA12 O43570 1/20 0.57
CA1 P00915 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17790725 0.82 CYP1A2 (0.73) CNR1CYP1A2CYP2D6CYP2C19NPC1
SCHEMBL8581580 0.81 IDO1 (0.68) CNR1IDO1CYP1A2CYP2D6CYP2C19
SCHEMBL23771086 0.81 MEN1 (0.78) CYP1A2CYP2D6CYP2C19NPC1RAB9A
SCHEMBL3654946 0.81 CA2 (0.52) CNR1NPC1RAB9AMAPTLMNA
SCHEMBL22834266 0.81 CNR1 (1.00) CNR1CYP1A2CYP2D6CYP2C19NPC1
SCHEMBL27821072 0.81 CNR1 (0.66) CNR1CYP1A2CYP2D6CYP2C19NPC1
SCHEMBL4582082 0.79 TAAR1 (0.65) CNR1IDO1CYP1A2CYP2D6CYP2C19
SCHEMBL16457166 0.79 EPHX1 (0.46) CNR1NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL1008891 0.78 KDM4E (0.70) CNR1IDO1CYP1A2CYP2D6CYP2C19
SCHEMBL5574769 0.78 LMNA (0.66) CNR1IDO1CYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110033393-A1 Hydrazone Compounds and Their Use REDPOINT BIO CORPORATION 2011-02-10 US disclosed
WO-2010132615-A1 HYDRAZONE COMPOUNDS AND THEIR USE STEIN PHILIP (US) 2010-11-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110033393-A1 Hydrazone Compounds and Their Use TRPM5, TRPV5, TRPM8 CNR1 235/4885IDO1 2488/4885CYP1A2 1053/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.