SCHEMBL12239158

SCHEMBL12239158

COC(=O)c1cnc(N2CCC(Oc3ccc(CN4CCCCC4)cc3Cl)CC2)nc1

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 9/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
SCN1A P35498 3/20 0.43
SCN8A Q9UQD0 3/20 0.43
ACHE P22303 1/20 0.42
ADRB2 P07550 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12239164 0.90 HRH1 (0.44) UTS2RACHE
SCHEMBL12239163 0.89 OPRK1 (0.43) UTS2RACHE
SCHEMBL1006057 0.89 SCN1A (0.43) UTS2RSCN1ASCN8A
SCHEMBL12239165 0.89 DGAT2 (0.48) UTS2RSCN1ASCN8A
SCHEMBL12239172 0.87 SMN1; SMN2 (0.43) UTS2RSCN1ASCN8AADRB2
SCHEMBL12239161 0.86 POLB (0.46) UTS2RSCN1ASCN8AACHE
SCHEMBL12239166 0.85 DGAT2 (0.50) UTS2RADRB2
SCHEMBL12239160 0.84 POLB (0.44) SCN1ASCN8A
SCHEMBL12239152 0.83 ADRB2 (0.43) LMNAADRB2
SCHEMBL12239159 0.83 SCD (0.49) ALDH1A1SCN1ASCN8A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110263557-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2011-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263557-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY GPR119, GPR55, NR1H2 UTS2R 265/4885ALDH1A1 2341/4885LMNA 3901/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.