SCHEMBL12239348

SCHEMBL12239348

Cc1cc(C)c(C2C(=O)CC(CC3CCN(C(=O)C(C)C)C3)C2=O)c(C)c1

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AOC2 O75106 1/20 0.36
MAOA P21397 1/20 0.36
DPP8 Q6V1X1 3/20 0.33
DPP7 Q9UHL4 2/20 0.33
FAAH O00519 1/20 0.33
SMYD3 Q9H7B4 4/20 0.33
MAPT P10636 1/20 0.32
EPHX2 P34913 1/20 0.31
DPP4 P27487 5/20 0.31
DPP9 Q86TI2 2/20 0.31
PDE4B Q07343 1/20 0.31
TLR9 Q9NR96 1/20 0.31
TLR8 Q9NR97 1/20 0.31
TLR7 Q9NYK1 1/20 0.31
NAMPT P43490 1/20 0.31
POLB P06746 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12239288 0.94 FAAH (0.36) FAAHMAPTEPHX2L3MBTL1
SCHEMBL12239243 0.88 BRD4 (0.36) MAPT
SCHEMBL12239347 0.86 FASN (0.37) MAPT
SCHEMBL12239350 0.85 ALDH1A1 (0.34) MAPTPOLB
SCHEMBL12239349 0.85 CXCR3 (0.32) AOC2MAPTEPHX2TLR9TLR8
SCHEMBL12239295 0.85 MEN1 (0.39) MAPTL3MBTL1
SCHEMBL12239250 0.85 THRB (0.34) MAPTEPHX2PDE4B
SCHEMBL12239369 0.84 DPP8 (0.33) DPP8DPP7MAPT
SCHEMBL12239232 0.84 MAPT (0.36) MAPT
SCHEMBL12239320 0.83 NPC1 (0.38) EPHX2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2313370-B1 5-HETEROCYCLYLALKYL-3-HYDROXY-2-PHENYLCYCLOPENT-2-ENONES AS HERBICIDES SYNGENTA LTD (GB) 2015-08-19 EP disclosed
US-9096560-B2 5-heterocyclylalkyl-3-hydroxy-2-phenylcyclopent-2-enones as herbicides SYNGENTA LIMITED (GB) 2015-08-04 US disclosed
US-9096560-B2 5-heterocyclylalkyl-3-hydroxy-2-phenylcyclopent-2-enones as herbicides SYNGENTA LIMITED (GB) 2015-08-04 US disclosed
US-20130053385-A1 METHOD OF COMBATING AND CONTROLLING PESTS SYNGENTA LIMITED (GB) 2013-02-28 US disclosed
US-20130053385-A1 METHOD OF COMBATING AND CONTROLLING PESTS SYNGENTA LIMITED (GB) 2013-02-28 US disclosed
US-20110263428-A1 5-HETEROCYCLYLALKYL-3-HYDROXY-2-PHENYLCYCLOPENT-2-ENONES AS HERBICIDES SYNGENTA CROP PROTECTION, INC. (US) 2011-10-27 US disclosed
WO-2010000773-A1 5-HETEROCYCLYLALKYL-3-HYDROXY-2-PHENYLCYCLOPENT-2-ENONES AS HERBICIDES SYNGENTA LIMITED (GB) 2010-01-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263428-A1 5-HETEROCYCLYLALKYL-3-HYDROXY-2-PHENYLCYCLOPENT-2-ENONES AS HERBICIDES DDT, CYP1B1, AHR AOC2 227/4885MAOA 1657/4885DPP8 2127/4885
US-20130053385-A1 METHOD OF COMBATING AND CONTROLLING PESTS ACHE, ALG1, KEAP1 AOC2 694/4885MAOA 767/4885DPP8 3487/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.