Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1224360 | 1.00 | MAPT (0.40) | MAPTKMT2ASAE1UBA2PKM | |
| SCHEMBL1225275 | 0.79 | GRM4 (0.41) | MAPTKMT2AHTTALOX15GRM4 | |
| SCHEMBL1225277 | 0.79 | GRM4 (0.41) | MAPTKMT2AHTTALOX15GRM4 | |
| SCHEMBL2398947 | 0.72 | ALDH1A1 (0.42) | MAPTKMT2APKMALDH1A1NPSR1 | |
| SCHEMBL1225252 | 0.72 | KMT2A (0.45) | MAPTKMT2AHTTALDH1A1NPSR1 | |
| SCHEMBL2398945 | 0.72 | ALDH1A1 (0.42) | MAPTKMT2APKMALDH1A1NPSR1 | |
| SCHEMBL1225255 | 0.72 | KMT2A (0.45) | MAPTKMT2AHTTALDH1A1NPSR1 | |
| SCHEMBL1224685 | 0.71 | LMNA (0.45) | MAPTKMT2AHTTALDH1A1NPSR1 | |
| SCHEMBL1224684 | 0.71 | LMNA (0.45) | MAPTKMT2AHTTALDH1A1NPSR1 | |
| SCHEMBL1288074 | 0.70 | L3MBTL1 (0.41) | MAPTKMT2AALDH1A1GRM4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193177-B2 | Hepatocyte growth factor pathway activators in fibrotic connective tissue diseases | ANGION BIOMEDICA CORP. (US) | 2012-06-05 | — | — | US | claimed |
| US-20100256117-A1 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | ANGION BIOMEDICA CORP. | 2010-10-07 | — | — | US | claimed |
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2003-11-20 | — | — | US | claimed |
| EP-1355921-A2 | MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF | North Shore-Long Island Jewish Health System (US) | 2003-10-29 | — | — | EP | claimed |
| US-6610726-B2 | Pyrazole derivative that mimics or agonizes hepatocyte growth factor/scatter factor; antiischemic agents | NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE | 2003-08-26 | — | — | US | claimed |
| US-20030045559-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM | 2003-03-06 | — | — | US | claimed |
| US-20030022924-A1 | Compositions and agents for modulating cellular proliferation and angiogenesis | PILLARISETTI SIVARAM (US) | 2003-01-30 | — | — | US | claimed |
| WO-2002002593-A2 | MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM (US) | 2002-01-10 | — | — | WO | claimed |
| US-7879898-B1 | treating a chronic obstructive pulmonary disease using modulators of HGF/SF activity; for example, 3-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-1-(4-chlorophenyl)prop-2-en-1-one; emphysema | ANGION BIOMEDICA CORP. (US) | 2011-02-01 | — | — | US | disclosed |
| WO-2009064422-A2 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | ANGION BIOMEDICA CORP. (US) | 2009-05-22 | — | — | WO | disclosed |
| US-20050096372-A1 | Small-molecule modulators of hepatocyte growth factor/scatter factor activities | PILLARISETTI SIVARAM (US) | 2005-05-05 | — | — | US | disclosed |
| US-6855728-B2 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM (US) | 2005-02-15 | — | — | US | disclosed |
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2003-11-20 | — | — | US | disclosed |
| US-6610726-B2 | Pyrazole derivative that mimics or agonizes hepatocyte growth factor/scatter factor; antiischemic agents | NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE | 2003-08-26 | — | — | US | disclosed |
| US-20030022924-A1 | Compositions and agents for modulating cellular proliferation and angiogenesis | PILLARISETTI SIVARAM (US) | 2003-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045559-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | HGF, HDGF, MET | MAPT 4612/4885KMT2A 4257/4885SAE1 2574/4885 |
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | HGF, HDGF, MET | MAPT 4612/4885KMT2A 4257/4885SAE1 2574/4885 |
| US-20050096372-A1 | Small-molecule modulators of hepatocyte growth factor/scatter factor activities | HGF, HDGF, MET | MAPT 4612/4885KMT2A 4257/4885SAE1 2574/4885 |
| US-20100256117-A1 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | HGF, HDGF, HGFAC | MAPT 4274/4885KMT2A 3623/4885SAE1 1221/4885 |
| US-20030022924-A1 | Compositions and agents for modulating cellular proliferation and angiogenesis | HGF, HDGF, MET | MAPT 4392/4885KMT2A 4643/4885SAE1 3480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.