Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Clorazepic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ALB | P02768 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.60 |
| ▸ | CCKBR | P32239 | 4/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clorazepic Acid SCHEMBL5185787 | 0.98 | LMNA (0.67) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL391416 | 0.98 | LMNA (0.67) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL4625002 | 0.98 | LMNA (0.67) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL314168 | 0.98 | LMNA (0.67) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL1576595 | 0.98 | LMNA (0.67) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL1302660 | 0.96 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL27617141 | 0.96 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL4287456 | 0.96 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL236792 | 0.96 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL21462311 | 0.95 | LMNA (0.70) | LMNAMEN1ALBKMT2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10859911-B2 | Multi-tone amplitude photomask | MARSUPIAL HOLDINGS, INC. (US) | 2020-12-08 | — | — | US | disclosed |
| US-20200117081-A1 | MULTI-TONE AMPLITUDE PHOTOMASK | MARSUPIAL HOLDINGS, INC. | 2020-04-16 | — | — | US | disclosed |
| US-20190302609-A1 | MULTI-TONE AMPLITUDE PHOTOMASK | MARSUPIAL HOLDINGS, INC. | 2019-10-03 | — | — | US | disclosed |
| US-10324372-B2 | Multi-tone amplitude photomask | MARSUPIAL HOLDINGS, INC. (US) | 2019-06-18 | — | — | US | disclosed |
| EP-3243107-A1 | MULTI-TONE AMPLITUDE PHOTOMASK | Marsupial Holdings LLC (US) | 2017-11-15 | — | — | EP | disclosed |
| US-20170299960-A1 | Multi-Tone Amplitude Photomask | MARSUPIAL HOLDINGS, INC. (US) | 2017-10-19 | — | — | US | disclosed |
| US-8168101-B2 | Inorganic membrane devices and methods of making and using the same | GENERAL ELECTRIC COMPANY (US) | 2012-05-01 | — | — | US | disclosed |
| US-20110042301-A1 | INORGANIC MEMBRANE DEVICES AND METHODS OF MAKING AND USING THE SAME | GENERAL ELECTRIC COMPANY (US) | 2011-02-24 | — | — | US | disclosed |