Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Clorazepic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ALB | P02768 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.60 |
| ▸ | CCKBR | P32239 | 4/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clorazepic Acid SCHEMBL391416 | 0.98 | LMNA (0.67) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL1225017 | 0.98 | LMNA (0.67) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL5185787 | 0.98 | LMNA (0.67) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL314168 | 0.98 | LMNA (0.67) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL1576595 | 0.98 | LMNA (0.67) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL1302660 | 0.96 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL27617141 | 0.96 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL4287456 | 0.96 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL236792 | 0.96 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL21462311 | 0.95 | LMNA (0.70) | LMNAMEN1ALBKMT2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103885300-A | Hydrophobic surface photoetching process | NANJING JING AO MICRO OPTOELECTRONIC TECHNOLOGY CO LTD | 2014-06-25 | — | — | CN | claimed |
| US-11074520-B2 | Extended coherence and single-shot readout of a silicon-vacancy spin in diamond | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-07-27 | — | — | US | disclosed |
| US-10969379-B2 | Nanoporous bioelectrochemical sensors for measuring redox potential in biological samples | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-04-06 | — | — | US | disclosed |
| US-20200184362-A1 | EXTENDED COHERENCE AND SINGLE-SHOT READOUT OF A SILICON-VACANCY SPIN IN DIAMOND | NATIONAL SCIENCE FOUNDATION | 2020-06-11 | — | — | US | disclosed |
| US-10451606-B2 | Nanoporous bioelectrochemical sensors for measuring redox potential in biological samples | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-22 | — | — | US | disclosed |
| WO-2019033009-A1 | EXTENDED COHERENCE AND SINGLE-SHOT READOUT OF A SILICON-VACANCY SPIN IN DIAMOND | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-02-14 | — | — | WO | disclosed |
| US-9728563-B2 | Combinatorial masking | APPLIED MATERIALS, INC. (US) | 2017-08-08 | — | — | US | disclosed |
| US-20160266090-A1 | Nanoporous Bioelectrochemical Sensors for Measuring Redox Potential in Biological Samples | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-09-15 | — | — | US | disclosed |
| US-20150279874-A1 | COMBINATORIAL MASKING | APPLIED MATERIALS, INC. (US) | 2015-10-01 | — | — | US | disclosed |
| WO-2015061250-A2 | NANOPOROUS BIOELECTROCHEMICAL SENSORS FOR MEASURING REDOX POTENTIAL IN BIOLOGICAL SAMPLES | DANIELS RODNEY C (US) | 2015-04-30 | — | — | WO | disclosed |
| EP-1193524-A2 | Micro-electro-mechanical mirror structure | Xerox Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1193529-A2 | Mirror structure | Xerox Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1193526-A1 | Mirror structure | Xerox Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1193522-A2 | Micro-electro-mechanical mirror structure manufacture | Xerox Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1193523-A2 | Micro-electro-mechanical mirror structure | Xerox Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1193530-A2 | Method of manufacturing a mirror structure | Xerox Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1193528-A2 | Method of manufacturing a mirror structure | Xerox Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| US-6300665-B1 | Structure for an optical switch on a silicon on insulator substrate | XEROX CORPORATION | 2001-10-09 | — | — | US | disclosed |
| EP-0188756-A2 | Method for polishing detector material | HONEYWELL INC. (US) | 1986-07-30 | — | — | EP | disclosed |
| US-4600469-A | Method for polishing detector material | HONEYWELL INC. (US) | 1986-07-15 | — | — | US | disclosed |