Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13229806 | 0.90 | LMNA (0.47) | MTNR1AMTNR1BAKR1C2HTR2BKDM4E | |
| SCHEMBL2001859 | 0.88 | AKR1C2 (0.60) | MTNR1AMTNR1BAKR1C2HTR2BKDM4E | |
| SCHEMBL13228543 | 0.86 | AKR1C2 (0.41) | MTNR1AMTNR1BAKR1C2PDE3BPDE3A | |
| SCHEMBL12255402 | 0.85 | AKR1C2 (0.44) | MTNR1AMTNR1BAKR1C2KDM4EGAA | |
| SCHEMBL12571223 | 0.84 | MTNR1A (0.42) | MTNR1AMTNR1BAKR1C2PDE3BPDE3A | |
| SCHEMBL12255237 | 0.84 | MTNR1A (0.46) | MTNR1AMTNR1BAKR1C2PDE3BPDE3A | |
| SCHEMBL12255320 | 0.82 | HTR1A (0.41) | MTNR1AMTNR1BPDE3BPDE3AHTR2B | |
| SCHEMBL13299828 | 0.81 | GAA (0.41) | MTNR1AMTNR1BAKR1C2KDM4EGAA | |
| SCHEMBL2427937 | 0.81 | MTNR1A (0.46) | MTNR1AMTNR1BAKR1C2PDE3BPDE3A | |
| SCHEMBL12571226 | 0.80 | PDE3B (0.48) | MTNR1AMTNR1BPDE3BPDE3AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481587-B2 | Substituted 2-(5-hydroxy-2-methyl-1H-indole-3-yl)acetic acids and ethers thereof and the use of same to treat viral diseases | IVASHCHENKO ANDREY ALEXANDROVICH (RU) | 2013-07-09 | — | — | US | disclosed |
| US-8481587-B2 | Substituted 2-(5-hydroxy-2-methyl-1H-indole-3-yl)acetic acids and ethers thereof and the use of same to treat viral diseases | IVASHCHENKO ANDREY ALEXANDROVICH (RU) | 2013-07-09 | — | — | US | disclosed |
| US-20110230524-A1 | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOLE-3-YL)ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES | ALLA CHEM, LLC. | 2011-09-22 | — | — | US | disclosed |
| US-20110230524-A1 | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOLE-3-YL)ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES | ALLA CHEM, LLC. | 2011-09-22 | — | — | US | disclosed |
| US-20090118503-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230524-A1 | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOLE-3-YL)ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES | IDO1, TPH1, FOXM1 | MTNR1A 62/4885MTNR1B 163/4885AKR1C2 87/4885 |
| US-20090118503-A1 | FAAH INHIBITORS | FAAH, FAAH2, CNR2 | MTNR1A 186/4885MTNR1B 104/4885AKR1C2 1010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.