Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.52 |
| ▸ | ORAI2 | Q96SN7 | 2/20 | 0.52 |
| ▸ | ORAI3 | Q9BRQ5 | 2/20 | 0.52 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | LPL | P06858 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | RRM1 | P23921 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7177934 | 0.85 | TRPV6 (0.52) | ORAI1ORAI2ORAI3TRPV6CYP2A6 | |
| SCHEMBL13383567 | 0.84 | CYP1A2 (0.42) | ORAI1ORAI2ORAI3TRPV6CA2 | |
| SCHEMBL12266163 | 0.81 | LPL (0.47) | LPLLIPGCYP2A6KMT2AMEN1 | |
| SCHEMBL5571942 | 0.80 | CYP1A2 (0.48) | ORAI1ORAI2ORAI3CYP2A6ALDH1A1 | |
| SCHEMBL2398463 | 0.77 | TSHR (0.38) | ALDH1A1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL29391558 | 0.76 | ALDH1A1 (0.48) | CYP2A6ALDH1A1CYP1A2TSHR | |
| SCHEMBL24488 | 0.76 | ALDH1A1 (0.48) | CYP2A6ALDH1A1CYP1A2TSHR | |
| SCHEMBL5601608 | 0.76 | ALDH1A1 (0.48) | CYP2A6ALDH1A1CYP1A2TSHR | |
| Phenyl Methyl Borinic Acid SCHEMBL8155181 | 0.76 | PCSK9 (0.37) | ORAI1ORAI2ORAI3TRPV6PCSK9 | |
| SCHEMBL12266207 | 0.72 | SIGMAR1 (0.43) | LPLLIPGCYP2A6ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853424-B2 | Protein cross-linking inhibitor | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8017809-B2 | Bisboron compound | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-09-13 | — | — | US | disclosed |
| US-20110212919-A1 | PROTEIN CROSS-LINKING INHIBITOR | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212919-A1 | PROTEIN CROSS-LINKING INHIBITOR | BAZ2B, PRMT1, BRIX1 | ORAI1 4605/4885ORAI2 3906/4885ORAI3 4036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.