Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.79 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.79 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.79 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.79 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.67 |
| ▸ | TTR | P02766 | 3/20 | 0.64 |
| ▸ | RELA | Q04206 | 3/20 | 0.63 |
| ▸ | NQO2 | P16083 | 3/20 | 0.61 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.61 |
| ▸ | ESR1 | P03372 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.61 |
| ▸ | BCR | P11274 | 2/20 | 0.61 |
| ▸ | AHR | P35869 | 2/20 | 0.61 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.61 |
| ▸ | TUBB | P07437 | 2/20 | 0.61 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Resveratrol 4'-Methyl Ether SCHEMBL563262 | 0.89 | PTGS2 (1.00) | PTGS2CYP1A1CYP1B1PTGS1KDM4E | |
| Resveratrol 4'-Methyl Ether SCHEMBL563261 | 0.89 | PTGS2 (1.00) | PTGS2CYP1A1CYP1B1PTGS1KDM4E | |
| Resveratrol 4'-Methyl Ether SCHEMBL4732963 | 0.89 | PTGS2 (1.00) | PTGS2CYP1A1CYP1B1PTGS1KDM4E | |
| SCHEMBL12231884 | 0.89 | RELA (0.73) | PTGS2CYP1A1CYP1B1PTGS1KDM4E | |
| SCHEMBL2516449 | 0.85 | PTGS2 (0.86) | PTGS2CYP1A1CYP1B1PTGS1KDM4E | |
| SCHEMBL29662231 | 0.85 | PTGS2 (0.86) | PTGS2CYP1A1CYP1B1PTGS1KDM4E | |
| SCHEMBL29652111 | 0.85 | PTGS2 (0.86) | PTGS2CYP1A1CYP1B1PTGS1KDM4E | |
| SCHEMBL2516446 | 0.85 | PTGS2 (0.86) | PTGS2CYP1A1CYP1B1PTGS1KDM4E | |
| SCHEMBL12535856 | 0.85 | PTGS2 (0.78) | PTGS2CYP1A1CYP1B1PTGS1KDM4E | |
| SCHEMBL15026080 | 0.85 | PTGS2 (0.85) | PTGS2CYP1A1CYP1B1PTGS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017634-B2 | Compositions for treating obesity and insulin resistance disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-09-13 | — | — | US | disclosed |
| EP-2289504-A2 | SIRT1 modulators for manipulating cell/organism lifespan/stress response | President and Fellows of Harvard College (US) | 2011-03-02 | — | — | EP | disclosed |
| US-7544497-B2 | Compositions for manipulating the lifespan and stress response of cells and organisms | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-06-09 | — | — | US | disclosed |