Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 8/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GRN | P28799 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12308274 | 0.89 | TAS1R3 (0.44) | P4HTMHPGDSCYP26A1L3MBTL1BAZ2B | |
| SCHEMBL12308201 | 0.86 | CYP26A1 (0.49) | CYP26A1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12308256 | 0.82 | CYP26A1 (0.55) | HPGDSCYP26A1L3MBTL1GAARAB9A | |
| SCHEMBL14136063 | 0.82 | HPGDS (0.38) | P4HTMHPGDSCYP26A1KDM4EALDH1A1 | |
| SCHEMBL12308120 | 0.81 | JMJD6 (0.46) | CYP26A1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29809632 | 0.81 | ECE1 (0.54) | CYP26A1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12308244 | 0.80 | TAS1R3 (0.43) | CYP26A1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12574370 | 0.78 | TAS1R3 (0.47) | CYP26A1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12308250 | 0.77 | CA1 (0.55) | CYP26A1GAACA1CA2CA12 | |
| SCHEMBL12334493 | 0.77 | CA2 (0.54) | HPGDSCYP26A1KDM4EL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140128571-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-05-08 | — | — | US | disclosed |
| US-20130165630-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2013-06-27 | — | — | US | disclosed |
| US-20120302780-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-11-29 | — | — | US | disclosed |
| US-20120302780-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-11-29 | — | — | US | disclosed |
| US-20110237776-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302780-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | CBS, ARSA, SOD1 | P4HTM 1302/4885HPGDS 935/4885CYP26A1 2288/4885 |
| US-20140128571-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | SOD1, CBS, ABCB7 | P4HTM 1591/4885HPGDS 1129/4885CYP26A1 2219/4885 |
| US-20110237776-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | SOD1, CBS, ABCB7 | P4HTM 1591/4885HPGDS 1129/4885CYP26A1 2219/4885 |
| US-20130165630-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | SOD1, CBS, ABCB7 | P4HTM 1591/4885HPGDS 1129/4885CYP26A1 2219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.