Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 5/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.59 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12338770 | 0.84 | MAPT (0.66) | MAPTPOLBTP53NPSR1TSHR | |
| SCHEMBL31451706 | 0.79 | MAPT (0.71) | MAPTPOLBTP53NPSR1TSHR | |
| SCHEMBL28092071 | 0.78 | MAPT (0.67) | MAPTPOLBNPSR1HTTLMNA | |
| SCHEMBL31451543 | 0.76 | MAPT (0.64) | MAPTPOLBTP53NPSR1TSHR | |
| SCHEMBL14642399 | 0.75 | MAPT (0.64) | MAPTTP53THRBKMT2A | |
| SCHEMBL14642395 | 0.75 | P2RX3 (0.63) | MAPTPOLBTP53HTTKDM4E | |
| SCHEMBL31451577 | 0.74 | MAPT (0.70) | MAPTTP53NPSR1TSHRLMNA | |
| SCHEMBL31451675 | 0.74 | MAPT (0.61) | MAPTTP53NPSR1TSHRLMNA | |
| SCHEMBL31451534 | 0.74 | MAPT (0.70) | MAPTTP53NPSR1TSHRLMNA | |
| SCHEMBL8026664 | 0.73 | MAPT (0.67) | MAPTHTTLMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263642-B2 | Antimicrobial compounds and methods of use thereof | VANDERBILT UNIVERSITY (US) | 2012-09-11 | — | — | US | disclosed |
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | VANDERBILT UNIVERSITY | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | HMOX1, HMOX2, NOD2 | MAPT 3448/4885POLB 3447/4885TP53 3383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.