Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31078214 | 0.87 | RORC (0.71) | HPGDSMN1; SMN2NPC1RAB9ATHRB | |
| SCHEMBL12334059 | 0.86 | MEN1 (0.67) | SMN1; SMN2NPC1RAB9ATP53RORC | |
| SCHEMBL12334640 | 0.85 | MEN1 (0.59) | SMN1; SMN2NPC1RAB9ARORCRXFP1 | |
| SCHEMBL12334263 | 0.85 | RORC (0.53) | SMN1; SMN2NPC1RAB9ARORCLMNA | |
| SCHEMBL12334247 | 0.84 | RAB9A (0.48) | SMN1; SMN2NPC1RAB9ATYK2RORC | |
| SCHEMBL21652185 | 0.84 | SMN1; SMN2 (0.74) | HPGDSMN1; SMN2NPC1RAB9ATHRB | |
| SCHEMBL12334253 | 0.83 | MEN1 (0.47) | MEN1KMT2AHSD11B1 | |
| SCHEMBL12334244 | 0.82 | TRPV1 (0.50) | SMN1; SMN2NPC1RAB9ATHRBTP53 | |
| SCHEMBL12334679 | 0.80 | RAB9A (0.56) | NPC1RAB9ATYK2MAPTGAA | |
| SCHEMBL15257990 | 0.80 | SMN1; SMN2 (0.82) | HPGDSMN1; SMN2NPC1RAB9ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115892-A1 | MODULATORS OF THE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTORS | GRIFFIN PATRICK R (US) | 2011-09-22 | — | — | WO | disclosed |