Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 9/20 | 0.58 |
| ▸ | RAB9A | P51151 | 9/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.54 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.54 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.54 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12334266 | 0.86 | HPGD (0.60) | MEN1KMT2ATDP1SMN1; SMN2LMNA | |
| SCHEMBL12334586 | 0.86 | RORC (0.72) | MEN1KMT2ATDP1SMN1; SMN2LMNA | |
| SCHEMBL12334263 | 0.85 | RORC (0.53) | MEN1KMT2ATDP1SMN1; SMN2LMNA | |
| SCHEMBL12334640 | 0.85 | MEN1 (0.59) | MEN1KMT2ATDP1SMN1; SMN2NPC1 | |
| SCHEMBL12334246 | 0.84 | RAB9A (0.61) | MEN1KMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL30266808 | 0.84 | MEN1 (0.73) | MEN1KMT2ATDP1SMN1; SMN2LMNA | |
| SCHEMBL12334252 | 0.84 | SNCA (0.56) | KMT2ATDP1SMN1; SMN2LMNANPC1 | |
| SCHEMBL12334628 | 0.84 | GPR27 (0.58) | KMT2ASMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL1687870 | 0.82 | MEN1 (0.69) | MEN1KMT2ATDP1SMN1; SMN2LMNA | |
| SCHEMBL12334679 | 0.80 | RAB9A (0.56) | MEN1KMT2ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115892-A1 | MODULATORS OF THE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTORS | GRIFFIN PATRICK R (US) | 2011-09-22 | — | — | WO | disclosed |