Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | TK1 | P04183 | 4/20 | 0.64 |
| ▸ | POLA1 | P09884 | 1/20 | 0.61 |
| ▸ | POLD1 | P28340 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TYMS | P04818 | 1/20 | 0.60 |
| ▸ | TK2 | O00142 | 1/20 | 0.60 |
| ▸ | ALB | P02768 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL23421401 | 1.00 | POLB (0.69) | POLBTK1POLA1POLD1LMNA | |
| Doxribtimine SCHEMBL154110 | 0.96 | POLB (0.72) | POLBTK1LMNASMN1; SMN2TYMS | |
| Doxribtimine SCHEMBL10427983 | 0.93 | TK1 (0.67) | POLBTK1LMNASMN1; SMN2TYMS | |
| Doxribtimine SCHEMBL887722 | 0.92 | TK1 (0.67) | POLBTK1LMNASMN1; SMN2TK2 | |
| Doxribtimine SCHEMBL8075845 | 0.92 | TK1 (0.67) | POLBTK1LMNASMN1; SMN2TK2 | |
| Doxribtimine SCHEMBL21682515 | 0.92 | TK1 (0.67) | POLBTK1LMNASMN1; SMN2TK2 | |
| Doxribtimine SCHEMBL176363 | 0.92 | TK1 (0.67) | POLBTK1LMNASMN1; SMN2TK2 | |
| Doxribtimine SCHEMBL77830 | 0.92 | TK1 (0.67) | POLBTK1LMNASMN1; SMN2TK2 | |
| Doxribtimine SCHEMBL22635984 | 0.92 | POLB (0.67) | POLBTK1LMNASMN1; SMN2TYMS | |
| Doxribtimine SCHEMBL7576317 | 0.91 | TK1 (0.66) | POLBTK1LMNASMN1; SMN2TK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114622001-A | Method for enhancing specificity, sensitivity and accuracy of polymerization reaction and nucleic acid detection | 四川大学 | 2022-06-14 | — | — | CN | claimed |
| CN-106282323-B | High-sensitivity DNA fluorescence analysis method for generating copper nanoparticles based on polythymine as template | 南京理工大学 | 2019-08-09 | — | — | CN | claimed |
| CN-106119343-B | One kind being based on Hg2+The MicroRNA detection method of auxiliary and double focusing synthase isothermal amplification | 南昌大学 | 2019-05-24 | — | — | CN | claimed |
| CN-107435075-A | Application and its kit and detection method of the astragalus polyose in ring mediated isothermal amplification | 重庆市畜牧科学院 | 2017-12-05 | — | — | CN | claimed |
| CN-107385086-A | Application and its kit and detection method of the dextran in ring mediated isothermal amplification | 重庆市畜牧科学院 | 2017-11-24 | — | — | CN | claimed |
| CN-107385084-A | Application and its kit and detection method of the astragalus polyose in ring mediated isothermal amplification | 重庆市畜牧科学院 | 2017-11-24 | — | — | CN | claimed |
| CN-106282323-A | High-sensitivity DNA fluorescence analysis method for generating copper nanoparticles based on polythymine as template | 南京理工大学 | 2017-01-04 | — | — | CN | claimed |
| CN-106119343-A | A kind of based on Hg2+auxiliary and the MicroRNA detection method of double focusing synthase isothermal amplification | 南昌大学 | 2016-11-16 | — | — | CN | claimed |
| CN-105886610-A | MicroRNA detection method based on in-situ generation of Cu-nanoclusters from thymine formed through extension of double polymerases | 南昌大学 | 2016-08-24 | — | — | CN | claimed |
| CN-1463292-A | Method for analyzing polynucleotide | VARY GENIX CORP (US) | 2003-12-24 | — | — | CN | claimed |
| CN-114622001-A | Method for enhancing specificity, sensitivity and accuracy of polymerization reaction and nucleic acid detection | 四川大学 | 2022-06-14 | — | — | CN | disclosed |
| CN-114622001-A | Method for enhancing specificity, sensitivity and accuracy of polymerization reaction and nucleic acid detection | 四川大学 | 2022-06-14 | — | — | CN | disclosed |
| CN-113004358-A | Selenium or thiothymidine-5' -triphosphate and synthesis method thereof | 纽奥维特(成都)生物科技有限公司 | 2021-06-22 | — | — | CN | disclosed |
| CN-106282323-B | High-sensitivity DNA fluorescence analysis method for generating copper nanoparticles based on polythymine as template | 南京理工大学 | 2019-08-09 | — | — | CN | disclosed |
| CN-110106231-A | A method of utilizing N6 or N1 generation methylation modifications of adenine in dUTP or dTTP detection nucleic acid | 武汉大学 | 2019-08-09 | — | — | CN | disclosed |
| CN-1039618-A | Detect the method for nucleotide sequence | ICI PLC (GB) | 1990-02-14 | — | — | CN | disclosed |
| CN-1006758-B | Method for preparing antineoplastic medicine composition | HADA KWITH (HU) | 1990-02-14 | — | — | CN | disclosed |
| CN-87101862-A | polypeptide, DNA and application thereof | — | 1987-10-21 | — | — | CN | disclosed |
| CN-85101341-A | Preparation of high purity protein and its application | — | 1987-01-31 | — | — | CN | disclosed |
| CN-85100625-A | Method for preparing antitumor medicinal composition | — | 1987-01-10 | — | — | CN | disclosed |