SCHEMBL1235136

SCHEMBL1235136

CC(C)(C)OC(=O)c1c(N)cc(Cl)nc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
ALDH1A1 P00352 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MAPK1 P28482 1/20 0.37
KDM4E B2RXH2 2/20 0.36
GLA P06280 2/20 0.36
GAA P10253 2/20 0.36
MAPT P10636 2/20 0.36
HPGD P15428 2/20 0.36
HIF1A Q16665 2/20 0.36
THRB P10828 1/20 0.36
GRM6 O15303 1/20 0.36
POLB P06746 1/20 0.36
ATR Q13535 1/20 0.35
CISD2 Q8N5K1 1/20 0.35
CA12 O43570 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30424032 1.00 HSP90AA1 (0.40) HSP90AA1HSP90AB1CYP2C9CYP2C19NPSR1
SCHEMBL16150656 0.84 ALDH1A1 (0.46) HSP90AA1HSP90AB1CYP2C9CYP2C19NPSR1
SCHEMBL12640799 0.82 ABL1 (0.44) NPSR1ALDH1A1SMN1; SMN2MAPK1KDM4E
SCHEMBL28569434 0.80 HSP90AA1 (0.39) HSP90AA1HSP90AB1CYP2C9CYP2C19NPSR1
SCHEMBL17541649 0.79 ALDH1A1 (0.47) HSP90AA1HSP90AB1CYP2C9CYP2C19NPSR1
SCHEMBL3757830 0.79 CACNA1B (0.41) HSP90AA1HSP90AB1CYP2C9CYP2C19NPSR1
SCHEMBL27809721 0.78 MAPT (0.37) HSP90AA1HSP90AB1CYP2C9CYP2C19NPSR1
SCHEMBL16149260 0.78 CYP2C9 (0.44) HSP90AA1HSP90AB1CYP2C9CYP2C19NPSR1
SCHEMBL1057673 0.78 ATR (0.44) CYP2C9CYP2C19NPSR1ATRCISD2
SCHEMBL31664072 0.78 ATR (0.44) CYP2C9CYP2C19NPSR1ATRCISD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4146220-B1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE AMGEN INC (US) 2026-02-18 EP disclosed
US-20250388574-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE AMGEN INC (US) 2025-12-25 US disclosed
US-12319691-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use AMGEN INC. (US) 2025-06-03 US disclosed
US-12252489-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use AMGEN INC. (US) 2025-03-18 US disclosed
US-20240190863-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE VIGIL NEUROSCIENCE, INC. 2024-06-13 US disclosed
US-20240124446-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE VIGIL NEUROSCIENCE, INC. 2024-04-18 US disclosed
US-11718617-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells2 agonists and methods of use AMGEN INC. (US) 2023-08-08 US disclosed
US-11718617-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells2 agonists and methods of use AMGEN INC. (US) 2023-08-08 US disclosed
US-11718617-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells2 agonists and methods of use AMGEN INC. (US) 2023-08-08 US disclosed
CN-116322696-A Heterocyclic compounds as receptor 2-triggering agonists expressed on myeloid cells and methods of use 安进公司 2023-06-23 CN disclosed
US-20230144581-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS2 AGONISTS AND METHODS OF USE VIGIL NEUROSCIENCE, INC. 2023-05-11 US disclosed
EP-4146220-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE Amgen Inc. (US) 2023-03-15 EP disclosed
WO-2021226135-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE AMGEN INC. (US) 2021-11-11 WO disclosed
WO-2021226135-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE AMGEN INC. (US) 2021-11-11 WO disclosed
US-20150299188-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-22 US disclosed
EP-2889291-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2015-07-01 EP disclosed
EP-2459558-A2 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2012-06-06 EP disclosed
WO-2011014795-A2 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-02-03 WO disclosed
EP-2250169-A1 PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS IRM LLC (BM) 2010-11-17 EP disclosed
WO-2009099801-A1 PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS IRM LLC (BM) 2009-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12252489-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use MSR1, FPR2, CD14 HSP90AA1 2831/4885HSP90AB1 2408/4885CYP2C9 1705/4885
US-20240190863-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE MSR1, FPR2, CD14 HSP90AA1 2831/4885HSP90AB1 2408/4885CYP2C9 1705/4885
US-12319691-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use MSR1, FPR2, CD14 HSP90AA1 3267/4885HSP90AB1 2919/4885CYP2C9 1526/4885
US-20150299188-A1 HETEROCYCLIC COMPOUND PTGIS, LIPG, FEN1 HSP90AA1 4030/4885HSP90AB1 3736/4885CYP2C9 3766/4885
US-20240124446-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE MSR1, FPR2, CD14 HSP90AA1 3267/4885HSP90AB1 2919/4885CYP2C9 1526/4885
US-11718617-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells2 agonists and methods of use MSR1, FPR2, CD14 HSP90AA1 3373/4885HSP90AB1 3033/4885CYP2C9 1455/4885
US-20230144581-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS2 AGONISTS AND METHODS OF USE MSR1, FPR2, CD14 HSP90AA1 3373/4885HSP90AB1 3033/4885CYP2C9 1455/4885
US-20250388574-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE MSR1, FCER2, HAVCR2 HSP90AA1 2347/4885HSP90AB1 1863/4885CYP2C9 3327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.