Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK5 | O95279 | 1/20 | 0.42 |
| ▸ | KCNK17 | Q96T54 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366170 | 0.88 | CNR1 (0.46) | P2RX7MAPK8RAB9AERCC1ERCC4 | |
| SCHEMBL12261238 | 0.83 | BDKRB1 (0.40) | P2RX7KCNA5KCNK3KCNK5KCNK17 | |
| SCHEMBL12366210 | 0.83 | ERCC1 (0.40) | P2RX7MEN1KMT2ARAB9AERCC1 | |
| SCHEMBL12366161 | 0.82 | RIPK1 (0.38) | P2RX7CARM1 | |
| SCHEMBL12366133 | 0.81 | HPGD (0.54) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12366166 | 0.80 | P2RX7 (0.49) | P2RX7 | |
| SCHEMBL23482150 | 0.80 | P2RX7 (0.56) | P2RX7MAOBMEN1KMT2AKCNA5 | |
| SCHEMBL4032263 | 0.80 | P2RX7 (0.53) | P2RX7MAOBMEN1KMT2AKCNA5 | |
| SCHEMBL30259905 | 0.80 | P2RX7 (0.56) | P2RX7MAOBMEN1KMT2AKCNA5 | |
| SCHEMBL23981793 | 0.80 | P2RX7 (0.53) | P2RX7MAOBMEN1KMT2AKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |