Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366137 | 0.82 | P2RX7 (0.50) | P2RX7CARM1 | |
| SCHEMBL12366170 | 0.82 | CNR1 (0.46) | CHRM4ROCK2ROCK1P2RX7 | |
| SCHEMBL12366210 | 0.80 | ERCC1 (0.40) | CHRM4P2RX7KDM4E | |
| SCHEMBL12366179 | 0.79 | P2RX7 (0.46) | RIPK1CHRM4P2RX7KDM4E | |
| SCHEMBL5481957 | 0.77 | CHRM4 (0.45) | RIPK1CHRM4ROCK2ROCK1FPR3 | |
| SCHEMBL12366166 | 0.77 | P2RX7 (0.49) | P2RX7 | |
| SCHEMBL28170731 | 0.77 | HPGD (0.44) | RIPK1CHRM4 | |
| SCHEMBL2262540 | 0.76 | MCL1 (0.46) | RIPK1CHRM4ROCK2ROCK1FPR3 | |
| SCHEMBL29788838 | 0.76 | RIPK1 (0.46) | RIPK1CHRM4ROCK2ROCK1FPR3 | |
| SCHEMBL12366133 | 0.75 | HPGD (0.54) | RIPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |