Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366133 | 0.88 | HPGD (0.54) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL12366166 | 0.86 | P2RX7 (0.49) | P2RX7 | |
| SCHEMBL12366161 | 0.79 | RIPK1 (0.38) | P2RX7KDM4ERIPK1CHRM4 | |
| SCHEMBL3558621 | 0.77 | P2RX7 (0.51) | P2RX7MAOBSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL12366210 | 0.76 | ERCC1 (0.40) | P2RX7SMN1; SMN2HPGDALDH1A1MEN1 | |
| SCHEMBL12366173 | 0.76 | P2RX7 (0.52) | P2RX7SMN1; SMN2HPGDALDH1A1MEN1 | |
| SCHEMBL12366170 | 0.76 | CNR1 (0.46) | P2RX7SMN1; SMN2ALDH1A1LMNARAB9A | |
| SCHEMBL12366196 | 0.76 | KMT2A (0.58) | P2RX7SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL2264097 | 0.76 | MCL1 (0.54) | P2RX7MAOBSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL12366137 | 0.76 | P2RX7 (0.50) | P2RX7MAOBMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |