Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.57 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.56 |
| ▸ | PRKACA | P17612 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | GSK3A | P49840 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.56 |
| ▸ | PRKX | P51817 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.56 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.56 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.56 |
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2249098 | 0.85 | PRKACA (0.56) | NPC1RAB9AROCK2RPS6KA5PRKACA | |
| SCHEMBL13813947 | 0.85 | PRKACA (0.56) | NPC1RAB9AROCK2RPS6KA5PRKACA | |
| SCHEMBL2247423 | 0.85 | PRKACA (0.56) | NPC1RAB9AROCK2RPS6KA5PRKACA | |
| SCHEMBL2245050 | 0.83 | NPC1 (0.52) | NPC1RAB9ATAS1R3TAS1R1ROCK2 | |
| SCHEMBL8246293 | 0.83 | RAB9A (0.52) | NPC1RAB9ATAS1R3TAS1R1ROCK2 | |
| SCHEMBL13813949 | 0.83 | RAB9A (0.52) | NPC1RAB9ATAS1R3TAS1R1ROCK2 | |
| SCHEMBL12366267 | 0.83 | PRKACA (0.54) | NPC1RAB9AROCK2RPS6KA5PRKACA | |
| SCHEMBL13169591 | 0.82 | TAS1R3 (0.70) | NPC1RAB9ATAS1R3TAS1R1HPGD | |
| SCHEMBL12366268 | 0.82 | RAB9A (1.00) | NPC1RAB9ATAS1R3TAS1R1HPGDS | |
| SCHEMBL18560572 | 0.82 | NPC1 (0.73) | NPC1RAB9ATAS1R3TAS1R1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2010-01-14 | — | — | US | disclosed |
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | ADAMTS5, ADAMTS1, ADAMTS7 | NPC1 3103/4885RAB9A 3609/4885TAS1R3 1826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.