Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 13/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366250 | 0.93 | MAPT (0.40) | MDM2MAPTCNR1ITGB1ITGA4 | |
| SCHEMBL12366472 | 0.91 | LMNA (0.45) | LMNAMDM2MAPTCNR1PTGS1 | |
| SCHEMBL12366288 | 0.91 | MDM2 (0.41) | MDM2 | |
| SCHEMBL12366330 | 0.91 | RGS4 (0.41) | LMNAMDM2MAPTTP53 | |
| SCHEMBL12366295 | 0.91 | ITGB1 (0.39) | MDM2MAPTCNR1ITGB1ITGA4 | |
| SCHEMBL12366493 | 0.91 | MDM2 (0.36) | MDM2MAPTCNR1ITGB1ITGA4 | |
| SCHEMBL12366342 | 0.91 | TP53 (0.41) | MDM2MAPTITGB1ITGA4ITGB7 | |
| SCHEMBL12366233 | 0.91 | CNR1 (0.42) | MDM2MAPTCNR1ITGB1ITGA4 | |
| SCHEMBL12366746 | 0.90 | PTGS2 (0.36) | MDM2MAPTITGB1ITGA4ITGB7 | |
| SCHEMBL12366256 | 0.90 | POLB (0.38) | LMNAMDM2MAPTCNR1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |