Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366250 | 0.94 | MAPT (0.40) | TP53MAPTMDM2P2RX3ITGB1 | |
| SCHEMBL12366330 | 0.92 | RGS4 (0.41) | TP53POLBMAPTKDM4EHPGD | |
| SCHEMBL12366295 | 0.92 | ITGB1 (0.39) | TP53MAPTHPGDMDM2ALDH1A1 | |
| SCHEMBL12366493 | 0.92 | MDM2 (0.36) | MAPTMDM2ITGB1ITGA4ITGB7 | |
| SCHEMBL12366288 | 0.92 | MDM2 (0.41) | MDM2 | |
| SCHEMBL12366233 | 0.92 | CNR1 (0.42) | TP53MAPTKDM4EHPGDMDM2 | |
| SCHEMBL12366495 | 0.91 | MDM2 (0.38) | MDM2ITGB1ITGA4ITGB7 | |
| SCHEMBL12366415 | 0.91 | CCR2 (0.41) | TP53POLBMAPTMDM2ALDH1A1 | |
| SCHEMBL12366746 | 0.91 | PTGS2 (0.36) | MAPTTRPC5MDM2ITGB1ITGA4 | |
| SCHEMBL12366335 | 0.91 | LMNA (0.35) | TP53MAPTMDM2ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |