Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366320 | 0.90 | KDM4E (0.47) | KDM4EHPGDEPHX2PPARGDCTPP1 | |
| SCHEMBL12366238 | 0.90 | DCTPP1 (0.42) | KDM4EHPGDPPARGDCTPP1CNR1 | |
| SCHEMBL12366212 | 0.90 | CNR1 (0.44) | KDM4EHPGDPPARGDCTPP1CNR1 | |
| SCHEMBL12366415 | 0.89 | CCR2 (0.41) | CCR2PKMEPHX2PPARGITGB1 | |
| SCHEMBL12366308 | 0.88 | RXRA (0.43) | KDM4EHPGDEPHX2DCTPP1CNR1 | |
| SCHEMBL12366275 | 0.88 | CFTR (0.42) | KDM4EHPGDPPARGDCTPP1CNR1 | |
| SCHEMBL12366313 | 0.87 | CNR1 (0.38) | KDM4EHPGDDCTPP1CNR1ITGB1 | |
| SCHEMBL12366245 | 0.87 | CNR1 (0.43) | KDM4EHPGDDCTPP1CNR1ITGB1 | |
| SCHEMBL12366485 | 0.86 | HPGD (0.40) | KDM4EHPGDPPARGDCTPP1CNR1 | |
| SCHEMBL12366421 | 0.86 | RXRA (0.39) | KDM4EHPGDPPARGDCTPP1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |