Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366238 | 0.93 | DCTPP1 (0.42) | RXRANR1H2NR1H3CNR1DCTPP1 | |
| SCHEMBL12366212 | 0.93 | CNR1 (0.44) | RXRANR1H2NR1H3CNR1DCTPP1 | |
| SCHEMBL12366275 | 0.91 | CFTR (0.42) | RXRANR1H2NR1H3CNR1DCTPP1 | |
| SCHEMBL12366320 | 0.91 | KDM4E (0.47) | RXRANR1H2NR1H3CNR1CYP11B1 | |
| SCHEMBL12366245 | 0.90 | CNR1 (0.43) | RXRANR1H2NR1H3CNR1DCTPP1 | |
| SCHEMBL12366313 | 0.90 | CNR1 (0.38) | RXRANR1H2NR1H3CNR1CYP11B1 | |
| SCHEMBL12366396 | 0.89 | RXRA (0.41) | RXRANR1H2NR1H3CNR1HPGD | |
| SCHEMBL12366421 | 0.89 | RXRA (0.39) | RXRANR1H2NR1H3CNR1DCTPP1 | |
| SCHEMBL12366330 | 0.88 | RGS4 (0.41) | RXRANR1H2NR1H3CYP11B1CYP11B2 | |
| SCHEMBL12366376 | 0.88 | RXRA (0.40) | RXRACNR1DCTPP1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |