Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 4/20 | 0.84 |
| ▸ | TUBB | P07437 | 4/20 | 0.84 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.84 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.84 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.84 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.84 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.84 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.84 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.84 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.84 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.84 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.84 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.84 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.84 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.79 |
| ▸ | P4HB | P07237 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18389685 | 1.00 | TUBB4A (0.84) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL26212394 | 1.00 | TUBB4A (0.84) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL836373 | 1.00 | TUBB4A (0.84) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL14669823 | 1.00 | TUBB4A (0.84) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL19601281 | 1.00 | TUBB4A (0.84) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL17213337 | 0.96 | TUBB4A (0.86) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL23193005 | 0.96 | TUBB4A (0.82) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL835527 | 0.96 | TUBB4A (0.85) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL12371281 | 0.96 | TUBB4A (0.85) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL835433 | 0.96 | TUBB4A (0.85) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239885-A1 | ANTIBODY CONJUGATE COMPRISING ANTI-P-CADHERIN ANTIBODY AND USES THEREOF | WuXi Biologics Ireland Limited (IE) | 2024-07-18 | — | — | US | disclosed |
| US-8524865-B2 | Antibodies and immunoconjugates and uses therefor | GENENTECH, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-8436147-B2 | Antibodies and immunoconjugates and uses therefor | GENENTECH, INC. (US) | 2013-05-07 | — | — | US | disclosed |
| US-7989434-B2 | Heterocyclic self-immolative linkers and conjugates | SEATTLE GENETICS, INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100278842-A1 | ANTI-EPHB2 ANTIBODIES AND METHODS USING SAME | GENENTECH, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100273843-A1 | HETEROCYCLIC SELF-IMMOLATIVE LINKERS AND CONJUGATES | SEAGEN INC. | 2010-10-28 | — | — | US | disclosed |
| US-7767205-B2 | Anti-EphB2 antibodies and methods using same | GENENTECH, INC. (US) | 2010-08-03 | — | — | US | disclosed |
| US-20090280056-A1 | Antibodies and immunoconjugates and uses therefor | GENENTECH, INC. | 2009-11-12 | — | — | US | disclosed |
| US-7521541-B2 | A free cysteine amino acid is a cysteine residue which has been engineered into the parent antibody and is not part of a disulfide bridge; diagnostics and therapeutics; killing or inhibiting the proliferation of tumor cells or cancer cells | GENETECH INC. (US) | 2009-04-21 | — | — | US | disclosed |
| US-20090068178-A1 | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin | GENENTECH, INC. (US) | 2009-03-12 | — | — | US | disclosed |
| US-20080254024-A1 | ANTI-EPHB2 ANTIBODIES AND METHODS USING SAME | GENENTECH, INC. (US) | 2008-10-16 | — | — | US | disclosed |
| US-7375078-B2 | Heterocyclic self-immolative linkers and conjugates | GENENTECH, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-20080050310-A1 | ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREFOR | GENENTECH, INC. (US) | 2008-02-28 | — | — | US | disclosed |
| US-20070092940-A1 | A free cysteine amino acid is a cysteine residue which has been engineered into the parent antibody and is not part of a disulfide bridge; diagnostics and therapeutics; killing or inhibiting the proliferation of tumor cells or cancer cells | GENENTECH, INC. (US) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090280056-A1 | Antibodies and immunoconjugates and uses therefor | STXBP1, WASF2, SDAD1 | TUBB4A 1373/4885TUBB 1457/4885TUBA3C 1328/4885 |
| US-20100278842-A1 | ANTI-EPHB2 ANTIBODIES AND METHODS USING SAME | EPHB2, EPHB3, EPHB1 | TUBB4A 104/4885TUBB 61/4885TUBA3C 123/4885 |
| US-20090068178-A1 | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin | HCLS1, CD47, MCL1 | TUBB4A 397/4885TUBB 550/4885TUBA3C 484/4885 |
| US-20240239885-A1 | ANTIBODY CONJUGATE COMPRISING ANTI-P-CADHERIN ANTIBODY AND USES THEREOF | CDH1, EPCAM, VIM | TUBB4A 226/4885TUBB 313/4885TUBA3C 198/4885 |
| US-20080050310-A1 | ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREFOR | CD22, CD2BP2, CD2 | TUBB4A 1843/4885TUBB 1954/4885TUBA3C 1536/4885 |
| US-20100273843-A1 | HETEROCYCLIC SELF-IMMOLATIVE LINKERS AND CONJUGATES | CTSL, DNPEP, CTSE | TUBB4A 1814/4885TUBB 1342/4885TUBA3C 1992/4885 |
| US-20080254024-A1 | ANTI-EPHB2 ANTIBODIES AND METHODS USING SAME | EPHB2, EPHB3, EPHB1 | TUBB4A 104/4885TUBB 61/4885TUBA3C 123/4885 |
| US-20070092940-A1 | A free cysteine amino acid is a cysteine residue which has been engineered into the parent antibody and is not part of a disulfide bridge; diagnostics and therapeutics; killing or inhibiting the proliferation of tumor cells or cancer cells | LNPEP, CSTB, ALB | TUBB4A 95/4885TUBB 40/4885TUBA3C 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.