Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 10/20 | 0.60 |
| ▸ | CTSK | P43235 | 10/20 | 0.60 |
| ▸ | CTSB | P07858 | 4/20 | 0.60 |
| ▸ | CTSL | P07711 | 2/20 | 0.60 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | REN | P00797 | 2/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12370618 | 0.90 | CTSS (0.58) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL12372036 | 0.90 | CTSK (0.57) | CTSSCTSKCTSBCTSLREN | |
| SCHEMBL12371630 | 0.87 | TACR1 (0.64) | CTSSCTSKCTSBCTSLHDAC8 | |
| SCHEMBL12371552 | 0.86 | CTSL (0.65) | CTSSCTSKCTSLACEKLK5 | |
| SCHEMBL4224863 | 0.86 | CTSK (0.65) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL4216378 | 0.86 | CTSK (0.65) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL3383006 | 0.84 | CTSS (0.77) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL4229789 | 0.81 | TACR1 (0.68) | CTSSCTSKCTSBCTSL | |
| SCHEMBL5190021 | 0.81 | TACR1 (0.68) | CTSSCTSKCTSBCTSL | |
| SCHEMBL27733229 | 0.81 | CTSS (0.65) | CTSSCTSKCTSBCTSLAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207726-A1 | Inhibitors of Human Cathepsin L, Cathepsin B, and Cathepsin S | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2011-08-25 | — | — | US | disclosed |
| WO-2009136997-A2 | INHIBITORS OF HUMAN CATHEPSIN L, CATHEPSIN B, AND CATHEPSIN S | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207726-A1 | Inhibitors of Human Cathepsin L, Cathepsin B, and Cathepsin S | CTSB, CTSS, CTSV | CTSS 2/4885CTSK 11/4885CTSB 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.