Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.57 |
| ▸ | REN | P00797 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 4/20 | 0.49 |
| ▸ | CTSL | P07711 | 3/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | CCKBR | P32239 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12370571 | 0.90 | CTSK (0.55) | CTSKRENCTSSCTSLCTSB | |
| SCHEMBL12371604 | 0.90 | CTSS (0.60) | CTSKRENCTSSCTSLCTSB | |
| SCHEMBL25283632 | 0.86 | CTSK (0.76) | CTSKRENCTSSCTSLCTSB | |
| SCHEMBL4214306 | 0.86 | CTSK (0.76) | CTSKRENCTSSCTSLCTSB | |
| SCHEMBL8418512 | 0.85 | REN (0.65) | CTSKRENCTSSCTSLCTSB | |
| SCHEMBL7373205 | 0.84 | REN (0.60) | CTSKRENCTSSCTSLCTSB | |
| SCHEMBL25286338 | 0.82 | CTSK (0.80) | CTSKCTSSCTSLCTSB | |
| SCHEMBL25293921 | 0.82 | CTSK (0.80) | CTSKCTSSCTSLCTSB | |
| SCHEMBL12371552 | 0.81 | CTSL (0.65) | CTSKCTSSCTSLCCKBR | |
| SCHEMBL12370618 | 0.80 | CTSS (0.58) | CTSKRENCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207726-A1 | Inhibitors of Human Cathepsin L, Cathepsin B, and Cathepsin S | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2011-08-25 | — | — | US | disclosed |
| WO-2009136997-A2 | INHIBITORS OF HUMAN CATHEPSIN L, CATHEPSIN B, AND CATHEPSIN S | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207726-A1 | Inhibitors of Human Cathepsin L, Cathepsin B, and Cathepsin S | CTSB, CTSS, CTSV | CTSK 11/4885REN 566/4885CTSS 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.