Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1061998 | 1.00 | KDM4E (0.55) | KDM4EHPGDLMNACYP1A2KMT2A | |
| SCHEMBL1240669 | 1.00 | KDM4E (0.55) | KDM4EHPGDLMNACYP1A2KMT2A | |
| SCHEMBL12268301 | 0.88 | MAOB (0.54) | KDM4EHPGDLMNACYP1A2KMT2A | |
| SCHEMBL5713385 | 0.84 | LMNA (0.33) | KDM4EHPGDLMNACYP1A2KMT2A | |
| SCHEMBL5713386 | 0.84 | LMNA (0.33) | KDM4EHPGDLMNACYP1A2KMT2A | |
| SCHEMBL1176839 | 0.81 | KMT2A (0.35) | KDM4EHPGDLMNACYP1A2KMT2A | |
| SCHEMBL27604931 | 0.80 | NFE2L2 (0.47) | GRM4NFE2L2 | |
| SCHEMBL5230319 | 0.80 | LMNA (0.36) | KDM4EHPGDLMNACYP1A2KMT2A | |
| SCHEMBL1288194 | 0.78 | RELA (0.55) | KDM4EKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL1238134 | 0.78 | RELA (0.55) | KDM4EKMT2AMEN1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180009793-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP (US) | 2018-01-11 | — | — | US | claimed |
| US-20140256727-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2014-09-11 | — | — | US | claimed |
| US-8772326-B2 | Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity | Anigion Biomedica Corp. (US) | 2014-07-08 | — | — | US | claimed |
| US-20140171419-A1 | ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP (US) | 2014-06-19 | — | — | US | claimed |
| US-20130190376-A1 | METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP | 2013-07-25 | — | — | US | claimed |
| US-20120190668-A1 | ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-07-26 | — | — | US | claimed |
| CN-102149379-A | Methods of modulating hepatocyte growth factor (scatter factor) activity and small molecule modulator compositions of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP | 2011-08-10 | — | — | CN | claimed |
| US-20110184038-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2011-07-28 | — | — | US | claimed |
| WO-2011019400-A2 | ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2011-02-17 | — | — | WO | claimed |
| US-10899750-B2 | Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2021-01-26 | — | — | US | disclosed |
| US-20180009793-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP (US) | 2018-01-11 | — | — | US | disclosed |
| US-20180009793-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP (US) | 2018-01-11 | — | — | US | disclosed |
| US-9663471-B2 | Pyrazole derivatives as modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663471-B2 | Pyrazole derivatives as modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |
| US-7265112-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265112-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7250437-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2007-07-31 | — | — | US | disclosed |
| US-7250437-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2007-07-31 | — | — | US | disclosed |
| US-7192976-B2 | 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity | ANGION BIOMEDICA CORPORATION (US) | 2007-03-20 | — | — | US | disclosed |
| US-7192976-B2 | 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity | ANGION BIOMEDICA CORPORATION (US) | 2007-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190668-A1 | ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, HGFAC | KDM4E 3771/4885HPGD 1643/4885LMNA 2598/4885 |
| US-20110184038-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, HGFAC | KDM4E 4796/4885HPGD 1390/4885LMNA 2470/4885 |
| US-20140256727-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, HGFAC | KDM4E 4796/4885HPGD 1390/4885LMNA 2470/4885 |
| US-10899750-B2 | Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity | HGF, HDGF, HGFAC | KDM4E 4780/4885HPGD 1456/4885LMNA 2697/4885 |
| US-20140171419-A1 | ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, MET | KDM4E 3736/4885HPGD 2633/4885LMNA 4548/4885 |
| US-20180009793-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, HGFAC | KDM4E 4796/4885HPGD 1390/4885LMNA 2470/4885 |
| US-20130190376-A1 | METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, HGFAC | KDM4E 4752/4885HPGD 1266/4885LMNA 3445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.