Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 7/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL636392 | 0.81 | TRPA1 (0.54) | TRPA1APPTP53TDP1LMNA | |
| SCHEMBL31158047 | 0.81 | TRPA1 (0.54) | TRPA1APPTP53TDP1LMNA | |
| SCHEMBL6836569 | 0.79 | CSNK2A1 (0.47) | TRPA1TP53TDP1LMNACHRM1 | |
| SCHEMBL30966773 | 0.78 | APP (0.52) | APPALOX15HSD17B10EP300KAT2B | |
| SCHEMBL11434258 | 0.78 | APP (0.55) | APPTP53TDP1LMNAALOX15 | |
| SCHEMBL5641724 | 0.77 | ALDH1A1 (0.43) | TRPA1TP53TDP1ALOX15ALDH1A1 | |
| SCHEMBL14524368 | 0.76 | TRPA1 (0.48) | TRPA1TP53TDP1LMNACHRM1 | |
| SCHEMBL21147112 | 0.76 | TRPA1 (0.43) | TRPA1TP53TDP1LMNACHRM1 | |
| SCHEMBL1367532 | 0.75 | TDP1 (0.44) | TRPA1TP53TDP1ALOX15ALDH1A1 | |
| SCHEMBL15490156 | 0.74 | TSHR (0.52) | APPTP53TDP1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170204084-A1 | NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVE ANTI-HIV ACTIVITY | VIROSTATICS SRL (IT) | 2017-07-20 | — | — | US | disclosed |
| US-9617225-B2 | 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity | VIROSTATICS SRL (IT) | 2017-04-11 | — | — | US | disclosed |
| US-20140057911-A1 | NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVING BOTH AROMATIC AND HALOGENIC SUBSTITUENTS | VIROSTATICS SRL (IT) | 2014-02-27 | — | — | US | disclosed |
| US-7985519-B2 | Aromatic polycarbonate, electrophotographic photoreceptor, and image forming apparatus | SHARP KABUSHIKI KAISHA (JP) | 2011-07-26 | — | — | US | disclosed |
| US-7985519-B2 | Aromatic polycarbonate, electrophotographic photoreceptor, and image forming apparatus | SHARP KABUSHIKI KAISHA (JP) | 2011-07-26 | — | — | US | disclosed |
| US-20100137578-A1 | CELLULOSE ESTER FILM FOR OPTICAL USE, AND POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY USING SUCH CELLULOSE ESTER FILM FOR OPTICAL USE | KONICA MINOLTA OPTO, INC. (JP) | 2010-06-03 | — | — | US | disclosed |
| US-20080199215-A1 | AROMATIC POLYCARBONATE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND IMAGE FORMING APPARATUS | SHARP KABUSHIKI KAISHA (JP) | 2008-08-21 | — | — | US | disclosed |
| US-20080199215-A1 | AROMATIC POLYCARBONATE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND IMAGE FORMING APPARATUS | SHARP KABUSHIKI KAISHA (JP) | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140057911-A1 | NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVING BOTH AROMATIC AND HALOGENIC SUBSTITUENTS | DPYD, ABL1, BRD4 | TRPA1 2102/4885APP 4549/4885TP53 135/4885 |
| US-20170204084-A1 | NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVE ANTI-HIV ACTIVITY | UMPS, DPYD, DUT | TRPA1 4508/4885APP 4442/4885TP53 2711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.