Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048904 | 0.91 | PTPN1 (0.58) | CTSSCTSKHDAC1HDAC4HDAC6 | |
| SCHEMBL2802961 | 0.84 | CTSS (0.69) | CTSSCTSKKLK5HDAC1HDAC6 | |
| SCHEMBL1826757 | 0.84 | CTSS (0.69) | CTSSCTSKKLK5HDAC1HDAC6 | |
| SCHEMBL10033679 | 0.84 | CTSS (0.69) | CTSSCTSKKLK5HDAC1HDAC6 | |
| SCHEMBL14962736 | 0.82 | TAS1R3 (0.52) | CTSSCTSKKLK5HDAC1HDAC4 | |
| SCHEMBL8883613 | 0.81 | HDAC4 (0.52) | CTSSCTSKKLK5HDAC1HDAC4 | |
| SCHEMBL8882062 | 0.81 | HDAC4 (0.52) | CTSSCTSKKLK5HDAC1HDAC4 | |
| SCHEMBL12889741 | 0.80 | CTSS (0.52) | CTSSCTSKKLK5HDAC1HDAC6 | |
| SCHEMBL7386138 | 0.79 | CTSS (0.54) | CTSSCTSKKLK5HDAC1HDAC6 | |
| SCHEMBL31407825 | 0.79 | ACE (0.58) | CTSSCTSKHDAC1HDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884204-B2 | such as (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinyl)phenyl]propionic acid, used for the teratment of inflammatory diseases, arthritis, inflammatory bowel diseases, lupus, multiple syndrome, asthma, psoriasis, allergies, diabetes and cardiovascular diseases | AJINOMOTO CO., INC. (JP) | 2011-02-08 | — | — | US | disclosed |
| US-7884204-B2 | such as (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinyl)phenyl]propionic acid, used for the teratment of inflammatory diseases, arthritis, inflammatory bowel diseases, lupus, multiple syndrome, asthma, psoriasis, allergies, diabetes and cardiovascular diseases | AJINOMOTO CO., INC. (JP) | 2011-02-08 | — | — | US | disclosed |
| US-7884204-B2 | such as (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinyl)phenyl]propionic acid, used for the teratment of inflammatory diseases, arthritis, inflammatory bowel diseases, lupus, multiple syndrome, asthma, psoriasis, allergies, diabetes and cardiovascular diseases | AJINOMOTO CO., INC. (JP) | 2011-02-08 | — | — | US | disclosed |
| US-20080280909-A1 | NEW PHENYLALANINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2008-11-13 | — | — | US | disclosed |
| US-20080280909-A1 | NEW PHENYLALANINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2008-11-13 | — | — | US | disclosed |
| US-7250516-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2007-07-31 | — | — | US | disclosed |
| US-7250516-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2007-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280909-A1 | NEW PHENYLALANINE DERIVATIVES | ITGB4, VCAM1, ITGA4 | CTSS 4143/4885CTSK 4482/4885KLK5 1869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.