Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12411239 | 0.82 | KMT2A (0.51) | KMT2AALDH1A1LMNAKDM4ERAB9A | |
| SCHEMBL2845203 | 0.82 | AKR1C1 (0.45) | KMT2AAKR1C1ALDH1A1MAPTLMNA | |
| SCHEMBL20414312 | 0.82 | KMT2A (0.51) | KMT2AALDH1A1LMNAKDM4ERAB9A | |
| SCHEMBL6031703 | 0.80 | TRPM8 (0.48) | KMT2AAKR1C1ALDH1A1MAPTLMNA | |
| SCHEMBL9446229 | 0.80 | TRPM8 (0.48) | KMT2AAKR1C1ALDH1A1MAPTLMNA | |
| SCHEMBL9446234 | 0.80 | TRPM8 (0.48) | KMT2AAKR1C1ALDH1A1MAPTLMNA | |
| SCHEMBL9446228 | 0.78 | ALDH1A1 (0.52) | KMT2AAKR1C1ALDH1A1MTNR1AMTNR1B | |
| SCHEMBL9446220 | 0.78 | ALDH1A1 (0.52) | KMT2AAKR1C1ALDH1A1MTNR1AMTNR1B | |
| SCHEMBL7904469 | 0.78 | ESR1 (0.45) | KMT2AAKR1C1ALDH1A1MAPTGAA | |
| SCHEMBL12411238 | 0.78 | LMNA (0.48) | KMT2AALDH1A1MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580990-B2 | Gold catalyzed hydroamination of alkynes and allenes | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-11-12 | — | — | US | disclosed |
| US-8580990-B2 | Gold catalyzed hydroamination of alkynes and allenes | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-11-12 | — | — | US | disclosed |
| US-20110166349-A1 | GOLD CATALYZED HYDROAMINATION OF ALKYNES AND ALLENES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166349-A1 | GOLD CATALYZED HYDROAMINATION OF ALKYNES AND ALLENES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166349-A1 | GOLD CATALYZED HYDROAMINATION OF ALKYNES AND ALLENES | AOC3, AOC2, AOC1 | KMT2A 984/4885AKR1C1 375/4885ALDH1A1 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.