Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.63 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.63 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.63 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | EPHX1 | P07099 | 9/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23481547 | 1.00 | PDK1 (0.63) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL9611267 | 0.98 | ALDH1A1 (0.61) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL12206764 | 0.93 | ALDH1A1 (0.61) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL4087474 | 0.88 | ALDH1A1 (0.60) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL21100016 | 0.88 | ALDH1A1 (0.60) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL18654098 | 0.86 | PDK1 (0.63) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL22110497 | 0.83 | PDK1 (0.59) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL942808 | 0.83 | PDK1 (0.59) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL10172721 | 0.83 | PDK1 (0.70) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL14243258 | 0.83 | PDK1 (0.59) | PDK1PDK2PDK3PDK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265103-A1 | NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME | TME THERAPEUTICS LLC | 2023-08-24 | — | — | US | disclosed |
| US-10752626-B2 | Iso-citrate dehydrogenase (IDH) inhibitor | SHANGHAI METON PHARMACEUTICAL CO., LTD (CN) | 2020-08-25 | — | — | US | disclosed |
| US-10550073-B2 | Benzamide derivative | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2020-02-04 | — | — | US | disclosed |
| US-20190256511-A1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | ZHEJIANG METON PHARMACEUTICAL CO., LTD (CN) | 2019-08-22 | — | — | US | disclosed |
| US-10266521-B2 | Substituted heteroaryl compounds and methods of use | CALITOR SCIENCES, LLC (US) | 2019-04-23 | — | — | US | disclosed |
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2018-08-09 | — | — | US | disclosed |
| US-20180215734-A1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE, INC. | 2018-08-02 | — | — | US | disclosed |
| US-10022354-B2 | Pyrrolidine amide compounds as histone demethylase inhibitors | GENENTECH, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-10022354-B2 | Pyrrolidine amide compounds as histone demethylase inhibitors | GENENTECH, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20180162841-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-06-14 | — | — | US | disclosed |
| CN-102001961-A | Method for synthesizing amide lanthanum complexes and application thereof in preparation of high-K material precursor | UNIV NANJING AERONAUTICS | 2011-04-06 | — | — | CN | disclosed |
| WO-2010128062-A1 | O-IMINO-ISO-UREA COMPOUNDS AND POLYMERIZABLE COMPOSITIONS THEREOF | BASF SE (DE) | 2010-11-11 | — | — | WO | disclosed |
| US-20100160574-A1 | Polymerisation Using Chain Transfer Agents | THE UNIVERSITY OF LEEDS (GB) | 2010-06-24 | — | — | US | disclosed |
| US-20100113502-A1 | Novel Tetrahydro-1H-Pyrido[4,3-b] Indole Derivatives as CB1 Receptor Ligands | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | US | disclosed |
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2009-10-29 | — | — | US | disclosed |
| US-20090215965-A1 | POLYMERISATION USING CHAIN TRANSFER AGENTS | THE UNIVERSITY OF LEEDS (GB) | 2009-08-27 | — | — | US | disclosed |
| US-7504391-B2 | Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders | SCHERING CORPORATION (US) | 2009-03-17 | — | — | US | disclosed |
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| US-7220532-B2 | Chemical amplification type resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-05-22 | — | — | US | disclosed |
| US-7220532-B2 | Chemical amplification type resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | BACE1, BACE2, APP | PDK1 4484/4885PDK2 4671/4885PDK3 4694/4885 |
| US-20180215734-A1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | DCK, TK1, DTYMK | PDK1 112/4885PDK2 145/4885PDK3 251/4885 |
| US-20100160574-A1 | Polymerisation Using Chain Transfer Agents | TRRAP, TRMT1, IPO11 | PDK1 3325/4885PDK2 4071/4885PDK3 4326/4885 |
| US-20230265103-A1 | NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME | PIKFYVE, PIK3CD, PIK3R5 | PDK1 436/4885PDK2 1240/4885PDK3 1185/4885 |
| US-20190256511-A1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | IDH3A, IDH2, IDH1 | PDK1 7/4885PDK2 20/4885PDK3 19/4885 |
| US-20180162841-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | PRKACA, PRKDC, PRKACB | PDK1 434/4885PDK2 608/4885PDK3 492/4885 |
| US-20090215965-A1 | POLYMERISATION USING CHAIN TRANSFER AGENTS | TRRAP, TRMT1, IPO11 | PDK1 3325/4885PDK2 4071/4885PDK3 4326/4885 |
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | MAP3K1, MAP3K15, MAP3K5 | PDK1 77/4885PDK2 138/4885PDK3 155/4885 |
| US-10550073-B2 | Benzamide derivative | CYP3A5, ABCB1, CYP2D6 | PDK1 1496/4885PDK2 1568/4885PDK3 1749/4885 |
| US-10752626-B2 | Iso-citrate dehydrogenase (IDH) inhibitor | IDH3A, IDH2, IDH1 | PDK1 7/4885PDK2 20/4885PDK3 19/4885 |
| US-10022354-B2 | Pyrrolidine amide compounds as histone demethylase inhibitors | KDM5A, KDM5C, KDM1B | PDK1 162/4885PDK2 375/4885PDK3 436/4885 |
| US-20100113502-A1 | Novel Tetrahydro-1H-Pyrido[4,3-b] Indole Derivatives as CB1 Receptor Ligands | CNR1, CNR2, OPRL1 | PDK1 2630/4885PDK2 3253/4885PDK3 2342/4885 |
| US-10266521-B2 | Substituted heteroaryl compounds and methods of use | PRKACA, PRKDC, PRKACB | PDK1 434/4885PDK2 608/4885PDK3 492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.