Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.46 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12414286 | 1.00 | DPP4 (0.46) | DPP4DPP8DPP9CHRNB2CHRNA3 | |
| SCHEMBL5396145 | 1.00 | DPP4 (0.46) | DPP4DPP8DPP9CHRNB2CHRNA3 | |
| SCHEMBL12413686 | 0.89 | CHRNB2 (0.43) | DPP4DPP8DPP9CHRNB2CHRNA3 | |
| SCHEMBL12414281 | 0.89 | CHRNB2 (0.43) | DPP4DPP8DPP9CHRNB2CHRNA3 | |
| SCHEMBL12414280 | 0.89 | CHRNB2 (0.43) | DPP4DPP8DPP9CHRNB2CHRNA3 | |
| SCHEMBL3059596 | 0.88 | MEN1 (0.47) | DPP4DPP8DPP9CHRNB2CHRNA3 | |
| SCHEMBL3397414 | 0.86 | DPP4 (0.45) | DPP4DPP8DPP9DPP7MEN1 | |
| SCHEMBL3424335 | 0.86 | DPP4 (0.45) | DPP4DPP8DPP9DPP7MEN1 | |
| SCHEMBL2249766 | 0.86 | DPP4 (0.45) | DPP4DPP8DPP9DPP7MEN1 | |
| SCHEMBL20385048 | 0.86 | DPP4 (0.45) | DPP4DPP8DPP9DPP7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190330224-A1 | ACC INHIBITORS AND USES THEREOF | Nimbus Apollo, Inc. | 2019-10-31 | — | — | US | disclosed |
| US-10179793-B2 | ACC inhibitors and uses thereof | GILEAD APOLLO, LLC (US) | 2019-01-15 | — | — | US | disclosed |
| US-20170145028-A1 | ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC (US) | 2017-05-25 | — | — | US | disclosed |
| US-20170145028-A1 | ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC (US) | 2017-05-25 | — | — | US | disclosed |
| WO-2017075056-A1 | ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC (US) | 2017-05-04 | — | — | WO | disclosed |
| US-8293729-B2 | Compounds, pharmaceutical composition and methods relating thereto | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-10-23 | — | — | US | disclosed |
| US-20110166116-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-07 | — | — | US | disclosed |
| WO-2010027236-A2 | FUSED HETEROCYCLIC COMPOUND | LG LIFE SCIENCES LTD. (KR) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145028-A1 | ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | DPP4 1148/4885DPP8 1339/4885DPP9 1065/4885 |
| US-10179793-B2 | ACC inhibitors and uses thereof | ACACA, ACACB, ACAT2 | DPP4 1148/4885DPP8 1339/4885DPP9 1065/4885 |
| US-20190330224-A1 | ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | DPP4 1148/4885DPP8 1339/4885DPP9 1065/4885 |
| US-20110166116-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO | MC2R, REN, CYP11B2 | DPP4 340/4885DPP8 786/4885DPP9 1058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.