Sugi Predict

Sugi Predict / Compounds / SCHEMBL12419740

SCHEMBL12419740

SCHEMBL12419740

OB(O)c1ccc(-c2nnc(-c3cccc4c3OC(F)(F)O4)o2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 8/20 0.37
▸ KDM4E B2RXH2 6/20 0.37
▸ HSD17B10 Q99714 3/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ RAB9A P51151 14/20 0.35
▸ NPC1 O15118 13/20 0.35
▸ SMN1; SMN2 Q16637 7/20 0.35
▸ HPGD P15428 6/20 0.35
▸ TSHR P16473 5/20 0.35
▸ MAPT P10636 3/20 0.35
▸ TP53 P04637 2/20 0.35
▸ NFKB1 P19838 1/20 0.35
▸ CASP3 P42574 1/20 0.35
▸ NFKB2 Q00653 1/20 0.35
▸ RELA Q04206 1/20 0.35
▸ SENP8 Q96LD8 1/20 0.35
▸ SENP7 Q9BQF6 1/20 0.35
▸ SENP6 Q9GZR1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12419575 0.78 ALDH1A1 (0.44) ALDH1A1KDM4EHSD17B10CYP1A2POLB
SCHEMBL12419558 0.78 STIM1 (0.39) ALDH1A1KDM4EHSD17B10CYP1A2POLB
SCHEMBL12419567 0.72 PARP1 (0.37) ALDH1A1KDM4EHSD17B10CYP1A2POLB
SCHEMBL12419559 0.71 RAB9A (0.53) ALDH1A1KDM4EHSD17B10CYP1A2POLB
SCHEMBL2816834 0.70 NPC1 (0.65) ALDH1A1KDM4EHSD17B10POLBRAB9A
SCHEMBL12419574 0.69 NPC1 (0.52) ALDH1A1KDM4EHSD17B10CYP1A2POLB
SCHEMBL12420280 0.69 MAOA (0.52) ALDH1A1KDM4EHSD17B10CYP1A2POLB
SCHEMBL12508694 0.68 SMN1; SMN2 (0.66) ALDH1A1KDM4EHSD17B10RAB9ANPC1
SCHEMBL16488121 0.68 ATR (0.48) ALDH1A1KDM4EHSD17B10CYP1A2CYP2C19
SCHEMBL12420282 0.67 RAB9A (0.36) ALDH1A1KDM4EHSD17B10CYP1A2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2015-12-24 — — US disclosed
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2015-12-24 — — US disclosed
US-8957049-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-02-17 — — US disclosed
US-8957049-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-02-17 — — US disclosed
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. 2011-07-14 — — US disclosed
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. 2011-07-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 ALDH1A1 354/4885KDM4E 1442/4885HSD17B10 93/4885
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 ALDH1A1 354/4885KDM4E 1442/4885HSD17B10 93/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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