SCHEMBL12424877

SCHEMBL12424877

CCc1ccc(F)c(C2=C3C(=O)NC(c4cc(C)ccc4F)=C3C(=O)N2)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.37
ALDH1A1 P00352 4/20 0.36
L3MBTL1 Q9Y468 3/20 0.36
MAPT P10636 3/20 0.36
LMNA P02545 2/20 0.36
NPC1 O15118 1/20 0.36
MAPK1 P28482 1/20 0.36
RAB9A P51151 1/20 0.36
GAA P10253 2/20 0.35
KDM4E B2RXH2 2/20 0.35
HPGD P15428 2/20 0.35
NISCH Q9Y2I1 1/20 0.35
SLC9A1 P19634 1/20 0.34
ROS1 P08922 1/20 0.34
CDK5 Q00535 1/20 0.34
ACVR1 Q04771 1/20 0.34
LRRK2 Q5S007 1/20 0.34
CDK2 P24941 1/20 0.33
GSK3B P49841 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12424869 0.88 NISCH (0.41) ALDH1A1L3MBTL1MAPTLMNANISCH
SCHEMBL23954121 0.81 ROS1 (0.43) HSD17B10SMN1; SMN2ALDH1A1MAPTLMNA
SCHEMBL12424902 0.80 PPOX (0.40) SMN1; SMN2ALDH1A1L3MBTL1MAPTLMNA
SCHEMBL12425004 0.78 CES1 (0.35) SMN1; SMN2L3MBTL1LMNANPC1RAB9A
SCHEMBL12425008 0.75 STK10 (0.44) ROS1CDK5ACVR1LRRK2
SCHEMBL12424872 0.72 CA9 (0.40) MAPTKDM4ELRRK2TGM2TDP1
SCHEMBL22625805 0.72 CDK2 (0.32) CDK2GSK3B
SCHEMBL22431171 0.71 EGFR (0.43) HSD17B10SMN1; SMN2ALDH1A1L3MBTL1MAPT
SCHEMBL12424887 0.71 PPOX (0.50) MAPTLMNACDK5ACVR1LRRK2
SCHEMBL12424972 0.71 TGM2 (0.46) HSD17B10MAPTLMNAMAPK1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed