SCHEMBL12425008

SCHEMBL12425008

Cc1ccc(F)c(C2=C3C(=O)NC(c4ccccc4C(F)(F)F)=C3C(=O)N2)c1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
STK10 O94804 9/20 0.44
SLK Q9H2G2 9/20 0.44
CES1 P23141 1/20 0.40
HSD11B1 P28845 2/20 0.38
ROS1 P08922 1/20 0.38
CDK5 Q00535 1/20 0.38
ACVR1 Q04771 1/20 0.38
LRRK2 Q5S007 1/20 0.38
ELANE P08246 1/20 0.36
PDK2 Q15119 1/20 0.36
CSNK1G1 Q9HCP0 1/20 0.36
AKR1C3 P42330 1/20 0.36
AKR1C2 P52895 1/20 0.36
JAK2 O60674 1/20 0.35
JAK1 P23458 1/20 0.35
JAK3 P52333 1/20 0.35
CHEK1 O14757 1/20 0.35
WEE1 P30291 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23954121 0.86 ROS1 (0.43) ROS1CDK5ACVR1LRRK2ELANE
SCHEMBL12424869 0.85 NISCH (0.41) ROS1CDK5ACVR1LRRK2ELANE
SCHEMBL12425005 0.84 JAK3 (0.53) STK10SLKCES1PDK2JAK2
SCHEMBL12424904 0.83 STK10 (0.51) STK10SLKCES1HSD11B1
SCHEMBL12425006 0.75 STK10 (0.56) STK10SLKCES1PDK2
SCHEMBL12424877 0.75 HSD17B10 (0.40) ROS1CDK5ACVR1LRRK2
SCHEMBL12425004 0.75 CES1 (0.35) CES1ROS1CDK5ACVR1LRRK2
SCHEMBL12424930 0.73 CES1 (0.50) STK10SLKCES1
SCHEMBL26375371 0.73 HSD11B1 (0.44) HSD11B1ELANEPDK2AKR1C3AKR1C2
SCHEMBL12509636 0.72 TDP2 (0.40) HSD11B1AKR1C3AKR1C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed