SCHEMBL1243555

SCHEMBL1243555

COCCN(CCOC)c1cc[c]cc1

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11315339 0.91 LMNA (0.32)
SCHEMBL27536450 0.90 CRHR1 (0.35) MEN1KMT2A
SCHEMBL18562084 0.84 KMT2A (0.37) MEN1KMT2A
SCHEMBL3040413 0.82 BRAF (0.34) MEN1KMT2A
SCHEMBL4652867 0.79
SCHEMBL20207410 0.78 ALDH1A1 (0.37) MEN1KMT2A
SCHEMBL3954915 0.78 MEN1 (0.46) MEN1KMT2A
SCHEMBL1244757 0.77 KCNA5 (0.33) MEN1KMT2A
SCHEMBL7794555 0.77 CYP2C19 (0.44)
SCHEMBL2038948 0.76 ALOX15 (0.42) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0605286-B1 Thermal-dye-bleach construction MINNESOTA MINING & MFG (US) 1998-06-24 EP claimed
EP-0403157-B1 Thermal dye bleach construction MINNESOTA MINING & MFG (US) 1995-01-11 EP claimed
EP-0605286-A1 Thermal-dye-bleach construction MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-07-06 EP claimed
US-5314795-A Thermal-dye-bleach construction comprising a polymethine dye and a thermal carbanion-generating agent MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-05-24 US claimed
EP-0269573-B1 LIQUID PHOTOINITIATING MIXTURE CIBA-GEIGY AG (CH) 1991-03-27 EP claimed
US-4960746-A A-HYDROXY-OR A-AMINO-ACETOPHENONES AND A TITANOCENE COMPOUND SUBSTITUTED BY FLUORINE CIBA-GEIGY CORPORATION (US) 1990-10-02 US claimed
EP-0269573-A2 Liquid photoinitiating mixture CIBA-GEIGY AG (CH) 1988-06-01 EP claimed
US-7879853-B2 tyrosisne kinase inhibitors such as N-[4-(6-Dibenzofuran-4-yl-pyrimidin-4-ylamino)-phenyl]-4-morpholin-4-yl-benzamide, used as anticasrcinogenic or antoproliferative agents, especially in the treatment of breast cancer BAYER SCHERING PHARMA AG (DE) 2011-02-01 US disclosed
EP-1763526-B1 4,6-DISUBSTITUTED PYRIMIDINES AND THEIR USE AS PROTEIN KINASE INHIBITORS BAYER SCHERING PHARMA AG (DE) 2009-06-24 EP disclosed
US-20070208034-A1 4,6-disubstituted pyrimidines and their use as protein kinase inhibitors ATLANTA PHARMA AG (DE) 2007-09-06 US disclosed
EP-1763526-A1 4,6-DISUBSTITUTED PYRIMIDINES AND THEIR USE AS PROTEIN KINASE INHIBITORS Altana Pharma AG (DE) 2007-03-21 EP disclosed
WO-2006000589-A1 4,6-DISUBSTITUTED PYRIMIDINES AND THEIR USE AS PROTEIN KINASE INHIBITORS ALTANA PHARMA AG (DE) 2006-01-05 WO disclosed
EP-1234007-B1 OLIGOMERIC METHINE DYES CLARIANT FINANCE BVI LTD (VG) 2004-02-18 EP disclosed
EP-0518470-A1 Negative-acting thermographic materials MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-12-16 EP disclosed
US-5135842-A Thermal nucleophile-generating agent and a polymethine dye MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-08-04 US disclosed
EP-0269573-B1 LIQUID PHOTOINITIATING MIXTURE CIBA-GEIGY AG (CH) 1991-03-27 EP disclosed
EP-0403157-A2 Thermal dye bleach construction MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-12-19 EP disclosed
US-4960746-A A-HYDROXY-OR A-AMINO-ACETOPHENONES AND A TITANOCENE COMPOUND SUBSTITUTED BY FLUORINE CIBA-GEIGY CORPORATION (US) 1990-10-02 US disclosed
EP-0269573-A2 Liquid photoinitiating mixture CIBA-GEIGY AG (CH) 1988-06-01 EP disclosed
US-4256458-A DIMERIC PYRIDINIUM DYES BASF AKTIENGESELLSCHAFT (DE) 1981-03-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208034-A1 4,6-disubstituted pyrimidines and their use as protein kinase inhibitors CDK2, DCK, DTYMK MEN1 3696/4885KMT2A 2628/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.