Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22305675 | 0.83 | CYP4F2 (0.35) | MAPTRAB9AATMNPC1SMN1; SMN2 | |
| SCHEMBL21241776 | 0.79 | GAA (0.40) | LMNAMAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL21241772 | 0.79 | CYP4F2 (0.43) | MAPTRAB9AL3MBTL1NOS1CYP4F2 | |
| SCHEMBL23705537 | 0.78 | LMNA (0.39) | LMNACYP4F2CYP4A11KDM4E | |
| SCHEMBL16427936 | 0.78 | LMNA (0.39) | LMNACYP4F2CYP4A11KDM4E | |
| SCHEMBL24737152 | 0.77 | NOS1 (0.41) | MAPTRAB9AATMNPC1SMN1; SMN2 | |
| SCHEMBL2749111 | 0.76 | MAPT (0.39) | MAPTRAB9AATMNPC1SMN1; SMN2 | |
| SCHEMBL22971546 | 0.76 | GAA (0.38) | LMNACYP4F2CYP4A11ALDH1A1GAA | |
| Pivalate SCHEMBL28032650 | 0.74 | RAB9A (0.39) | LMNAMAPTRAB9AATMNPC1 | |
| SCHEMBL29750493 | 0.73 | ALDH1A1 (0.41) | LMNAMAPTRAB9AATMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |
| WO-2011095997-A1 | BENZAMIDE COMPOUNDS AS GLUCOKINASE ACTIVATORS AND THEIR PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-08-11 | — | — | WO | disclosed |