Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.33 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10310593 | 0.86 | SIRT2 (0.41) | HDAC4EP300MEF2D | |
| SCHEMBL20010470 | 0.80 | SIRT2 (0.39) | HDAC4EP300MEF2D | |
| SCHEMBL11955676 | 0.77 | SIRT2 (0.37) | HDAC4EP300MEF2D | |
| SCHEMBL12252028 | 0.77 | ALDH1A1 (0.34) | ALDH1A1NPSR1KDM4EMEN1KMT2A | |
| SCHEMBL10310591 | 0.75 | ALDH1A1 (0.35) | ALDH1A1NPSR1KDM4EMEN1KMT2A | |
| SCHEMBL10310590 | 0.73 | ALDH1A1 (0.37) | ALDH1A1NPSR1KDM4EMEN1KMT2A | |
| SCHEMBL327667 | 0.73 | SIRT1 (0.36) | AKT1 | |
| SCHEMBL13448309 | 0.71 | POLB (0.35) | ALDH1A1NPSR1KDM4EMEN1KMT2A | |
| SCHEMBL12497446 | 0.71 | CPB1 (0.36) | — | |
| SCHEMBL2610530 | 0.71 | POLB (0.36) | ALDH1A1KDM4EHTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994272-B2 | Maleamic acid polymer derivatives and their bioconjugates | NEKTAR THERAPEUTICS (US) | 2011-08-09 | — | — | US | disclosed |
| US-20100113329-A1 | Maleamic Acid Polymer Derivatives and Their Bioconjugates | NEKTAR THERAPEUTICS (US) | 2010-05-06 | — | — | US | disclosed |
| US-7329721-B2 | Maleamic acid polymer derivatives and their bioconjugates | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2008-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113329-A1 | Maleamic Acid Polymer Derivatives and Their Bioconjugates | F13A1, ASS1, PSAT1 | ALDH1A1 1202/4885NPSR1 3554/4885KDM4E 2835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.