Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10047304 | 1.00 | ALDH1A1 (0.64) | ALDH1A1POLBCA2CA12CA9 | |
| SCHEMBL29113394 | 0.89 | ALDH1A1 (0.66) | ALDH1A1POLBCA2CA12CA9 | |
| SCHEMBL29113399 | 0.89 | ALDH1A1 (0.66) | ALDH1A1POLBCA2CA12CA9 | |
| SCHEMBL16802983 | 0.88 | ALDH1A1 (0.78) | ALDH1A1POLBCA2CA12CA9 | |
| SCHEMBL307938 | 0.88 | ALDH1A1 (0.78) | ALDH1A1POLBCA2CA12CA9 | |
| SCHEMBL10073012 | 0.88 | ALDH1A1 (0.78) | ALDH1A1POLBCA2CA12CA9 | |
| SCHEMBL21939418 | 0.86 | ALDH1A1 (0.55) | ALDH1A1POLBCA2CA12CA9 | |
| SCHEMBL12516171 | 0.81 | ALDH1A1 (0.68) | ALDH1A1POLBCA2CA12CA9 | |
| SCHEMBL12444230 | 0.81 | ALDH1A1 (0.68) | ALDH1A1POLBCA2CA12CA9 | |
| SCHEMBL12444212 | 0.81 | ALDH1A1 (0.68) | ALDH1A1POLBCA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10197557-B2 | Small molecules for endothelial cell activation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-02-05 | — | — | US | disclosed |
| US-8815935-B2 | Inhibitors of protein prenyltransferases | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-08-26 | — | — | US | disclosed |
| US-8815935-B2 | Inhibitors of protein prenyltransferases | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130310417-A1 | Small Molecules For Endothelial Cell Activation | THE REGENTS OF THE UNIVERSITY FO CALIFORNIA (US) | 2013-11-21 | — | — | US | disclosed |
| US-20130102639-A1 | INHIBITORS OF PROTEIN PRENYLTRANSFERASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-04-25 | — | — | US | disclosed |
| US-20130102639-A1 | INHIBITORS OF PROTEIN PRENYLTRANSFERASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-04-25 | — | — | US | disclosed |
| WO-2012116181-A2 | SMALL MOLECULES FOR ENDOTHELIAL CELL ACTIVATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-30 | — | — | WO | disclosed |
| US-20110178138-A1 | INHIBITORS OF PROTEIN PRENYLTRANSFERASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-07-21 | — | — | US | disclosed |
| US-20110178138-A1 | INHIBITORS OF PROTEIN PRENYLTRANSFERASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102639-A1 | INHIBITORS OF PROTEIN PRENYLTRANSFERASES | RABGGTA, FNTA, RABGGTB | ALDH1A1 2160/4885POLB 3212/4885CA2 4616/4885 |
| US-20130310417-A1 | Small Molecules For Endothelial Cell Activation | LIPG, VCAM1, SELE | ALDH1A1 3849/4885POLB 3434/4885CA2 1812/4885 |
| US-10197557-B2 | Small molecules for endothelial cell activation | LIPG, VCAM1, SELE | ALDH1A1 3849/4885POLB 3434/4885CA2 1812/4885 |
| US-20110178138-A1 | INHIBITORS OF PROTEIN PRENYLTRANSFERASES | RABGGTA, FNTA, RABGGTB | ALDH1A1 2160/4885POLB 3212/4885CA2 4616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.