Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 2/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | HNF4A | P41235 | 1/20 | 0.36 |
| ▸ | ADH1B | P00325 | 1/20 | 0.35 |
| ▸ | ADH1C | P00326 | 1/20 | 0.35 |
| ▸ | ADH1A | P07327 | 1/20 | 0.35 |
| ▸ | ADH7 | P40394 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245072 | 0.87 | DAO (0.42) | IDH1ALDH1A1MAOAMAOB | |
| SCHEMBL17398597 | 0.83 | RARA (0.41) | RARARXRALTA4HMAOAMAOB | |
| SCHEMBL17398385 | 0.83 | PNMT (0.41) | RARARXRAALDH1A1LMNALTA4H | |
| SCHEMBL27971613 | 0.82 | TSHR (0.50) | LTA4HMAOAMAOB | |
| SCHEMBL8226394 | 0.75 | RARA (0.39) | CALM1IDH1RARARXRAALDH1A1 | |
| SCHEMBL5360941 | 0.74 | RXRA (0.70) | RARARXRA | |
| SCHEMBL934450 | 0.74 | — | — | |
| SCHEMBL27719076 | 0.74 | IDH1 (0.58) | CALM1IDH1ALDH1A1PLA2G10PLA2G2A | |
| SCHEMBL31349737 | 0.73 | AKR1B1 (0.39) | RARARXRAALDH1A1LMNA | |
| SCHEMBL1244711 | 0.73 | KMT2A (0.57) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| CN-101820760-A | Condensed hetero ring | SEPRACOR INC | 2010-09-01 | — | — | CN | disclosed |
| EP-2173170-A2 | FUSED HETEROCYCLES | Sepracor Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| US-20100029741-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2010-02-04 | — | — | US | disclosed |
| US-20100022612-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2010-01-28 | — | — | US | disclosed |
| US-7579370-B2 | Fused heterocycles | SEPRACOR INC. (US) | 2009-08-25 | — | — | US | disclosed |
| CN-101511832-A | Fused heterocyclic inhibitors of D-amino acid oxidase | SEPRACOR INC (US) | 2009-08-19 | — | — | CN | disclosed |
| EP-2057162-A2 | FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | Sepracor Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2009020814-A2 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2009-02-12 | — | — | WO | disclosed |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | SEPRACOR INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | SEPRACOR INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | SEPRACOR INC. (US) | 2008-03-06 | — | — | US | disclosed |
| WO-2008005456-A2 | FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008005456-A2 | FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-10 | — | — | WO | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
| US-20080004328-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022612-A1 | FUSED HETEROCYCLES | AHR, HAX1, HRH3 | CALM1 3790/4885IDH1 90/4885RARA 2595/4885 |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | DAO, DDO, AOX1 | CALM1 1211/4885IDH1 732/4885RARA 2330/4885 |
| US-20100029741-A1 | FUSED HETEROCYCLES | CHRNA4, CHRNB4, CHRNA3 | CALM1 1917/4885IDH1 156/4885RARA 2955/4885 |
| US-20080004328-A1 | FUSED HETEROCYCLES | HRH3, HRH4, AHR | CALM1 3574/4885IDH1 93/4885RARA 2560/4885 |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | DAO, DDO, AOX1 | CALM1 1892/4885IDH1 569/4885RARA 2673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.