Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050197 | 0.79 | RAB9A (0.49) | MAPK1PTGS2KDM4EALDH1A1TDP1 | |
| SCHEMBL17995120 | 0.75 | TRPV4 (0.36) | MAPK1PTGS2KDM4EALDH1A1TDP1 | |
| SCHEMBL22206926 | 0.72 | PTGS2 (0.33) | MAPK1PTGS2KDM4EALDH1A1TDP1 | |
| SCHEMBL31433034 | 0.72 | MGLL (0.38) | — | |
| SCHEMBL6156185 | 0.71 | LMNA (0.37) | MAPK1PTGS2ALDH1A1NPC1RAB9A | |
| SCHEMBL3517559 | 0.71 | MAPK1 (0.73) | MAPK1PTGS2ALDH1A1NPC1RAB9A | |
| SCHEMBL1420171 | 0.70 | KMT2A (0.58) | MAPK1PTGS2ALDH1A1NPC1RAB9A | |
| SCHEMBL13732956 | 0.70 | SPR (0.32) | MAPK1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL619113 | 0.68 | HTT (0.36) | MAPK1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29284672 | 0.68 | PTGS2 (0.30) | MAPK1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133348-B1 | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2011-08-31 | — | — | EP | disclosed |
| EP-1618092-B1 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2010-09-22 | — | — | EP | disclosed |