Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PTGES | O14684 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12459463 | 0.84 | CYP3A4 (0.67) | CYP3A4CYP2C19CYP2D6CYP2C9RECQL | |
| SCHEMBL10029330 | 0.76 | CYP3A4 (0.44) | CYP3A4CYP2C19CYP2D6CYP2C9RECQL | |
| SCHEMBL11996353 | 0.76 | MAPT (0.62) | CYP3A4CYP2C19CYP2D6CYP2C9RECQL | |
| SCHEMBL12459467 | 0.74 | LMNA (0.69) | ALDH1A1HTTKMT2ALMNATSHR | |
| SCHEMBL13905646 | 0.74 | TSHR (0.67) | CYP3A4CYP2C19CYP2D6CYP2C9RECQL | |
| SCHEMBL6432060 | 0.74 | ALDH1A1 (0.60) | ALDH1A1HTTMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL12378964 | 0.74 | THRB (0.49) | CYP3A4CYP2C19CYP2D6CYP2C9ALDH1A1 | |
| SCHEMBL6405909 | 0.70 | SMN1; SMN2 (0.74) | CYP3A4CYP2C19CYP2D6CYP2C9RECQL | |
| SCHEMBL879231 | 0.70 | SLC22A12 (0.49) | CYP3A4CYP2C19CYP2D6CYP2C9ALDH1A1 | |
| SCHEMBL12459461 | 0.69 | KMT2A (0.63) | ALDH1A1HTTL3MBTL1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2353593-A1 | Non-nucleoside reverse transcriptase inhibitors | Ardea Biosciences, Inc. (US) | 2011-08-10 | — | — | EP | disclosed |
| EP-1545483-B1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES INC (US) | 2011-04-06 | — | — | EP | disclosed |
| US-20080249131-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| US-20080249131-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249131-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | POLRMT, TYMP, RNGTT | CYP3A4 1053/4885CYP2C19 1337/4885CYP2D6 1317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.