Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 5/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | FABP1 | P07148 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247211 | 0.95 | FFAR4 (0.42) | PPARDNR1H4GPBAR1PPARGPPARA | |
| SCHEMBL1245358 | 0.89 | NR1H4 (0.42) | PPARDNR1H4LPAR1GPBAR1MAPT | |
| SCHEMBL2334588 | 0.86 | LPAR1 (0.40) | PPARDNR1H4LPAR1PPARGPPARA | |
| SCHEMBL1245176 | 0.86 | NR1H4 (0.40) | PPARDNR1H4LPAR1GPBAR1MAPT | |
| SCHEMBL1247564 | 0.85 | MAPT (0.42) | NR1H4GPBAR1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1246477 | 0.84 | NR1H4 (0.42) | PPARDNR1H4GPBAR1PPARGPPARA | |
| SCHEMBL1246467 | 0.84 | NR1H4 (0.43) | PPARDNR1H4LPAR1GPBAR1FABP1 | |
| SCHEMBL1246442 | 0.84 | ALDH1A1 (0.39) | GPBAR1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL1245294 | 0.83 | GPBAR1 (0.37) | GPBAR1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1246476 | 0.83 | NR1H4 (0.42) | PPARDNR1H4LPAR1GPBAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |