Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245358 | 0.91 | NR1H4 (0.42) | ALDH1A1GPBAR1MAPTSCN9ACYP2C19 | |
| SCHEMBL1245176 | 0.87 | NR1H4 (0.40) | ALDH1A1GPBAR1MAPTSCN9ACYP2C19 | |
| SCHEMBL1246467 | 0.86 | NR1H4 (0.43) | GPBAR1SCN9APTGS2 | |
| SCHEMBL1246477 | 0.86 | NR1H4 (0.42) | ALDH1A1GPBAR1MAPT | |
| SCHEMBL1247211 | 0.85 | FFAR4 (0.42) | ALDH1A1GPBAR1KMT2AMAPTCYP2C19 | |
| SCHEMBL2336634 | 0.85 | LPAR1 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL1246476 | 0.85 | NR1H4 (0.42) | ALDH1A1GPBAR1MAPT | |
| SCHEMBL1247564 | 0.85 | MAPT (0.42) | ALDH1A1GPBAR1MAPTSCN9ATDP1 | |
| SCHEMBL1246285 | 0.84 | PPARD (0.43) | ALDH1A1GPBAR1KMT2AMAPTCYP2C19 | |
| SCHEMBL1245335 | 0.84 | NR1H4 (0.50) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |