Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602729 | 0.85 | L3MBTL1 (0.74) | L3MBTL1ALDH1A1ALOX5SMN1; SMN2PTGDR2 | |
| SCHEMBL7455571 | 0.79 | ALDH1A1 (0.60) | L3MBTL1HPGDALDH1A1NPSR1NPC1 | |
| SCHEMBL7456488 | 0.77 | ALDH1A1 (0.65) | L3MBTL1HPGDALDH1A1NPSR1NPC1 | |
| SCHEMBL6840453 | 0.75 | L3MBTL1 (0.55) | L3MBTL1HPGDALDH1A1NPSR1NPC1 | |
| SCHEMBL5238288 | 0.74 | L3MBTL1 (0.58) | L3MBTL1HPGDALDH1A1PTGDR2KDM4E | |
| SCHEMBL6502484 | 0.74 | L3MBTL1 (0.58) | L3MBTL1ALDH1A1ALOX5NPC1SMN1; SMN2 | |
| SCHEMBL6608210 | 0.74 | PTGDR2 (0.63) | L3MBTL1HPGDALDH1A1PTGDR2KDM4E | |
| SCHEMBL9628554 | 0.73 | TRPM8 (0.62) | L3MBTL1ALOX5MAPTPTGDR2TRPM8 | |
| SCHEMBL13407796 | 0.73 | ALDH1A1 (1.00) | L3MBTL1HPGDALDH1A1NPSR1NPC1 | |
| SCHEMBL6503373 | 0.72 | L3MBTL1 (0.57) | L3MBTL1HPGDALDH1A1ALOX5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278969-A2 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2010011375-A2 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2010-01-28 | — | — | WO | disclosed |