Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 4/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP3 | P08254 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.40 |
| ▸ | MMP8 | P22894 | 3/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1279796 | 0.85 | GPR119 (0.51) | ALDH1A1SMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL1279405 | 0.85 | GPR119 (0.51) | ALDH1A1SMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL1279798 | 0.85 | GPR119 (0.51) | ALDH1A1SMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL1279402 | 0.85 | GPR119 (0.51) | ALDH1A1SMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL7199941 | 0.80 | NPY2R (0.48) | ALDH1A1SMN1; SMN2RAB9ANPC1MMP13 | |
| SCHEMBL12468859 | 0.79 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL12468609 | 0.79 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL4709679 | 0.75 | PRMT5 (0.64) | ALDH1A1SMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL12468497 | 0.74 | MMP13 (0.44) | ALDH1A1MMP13MMP2MMP3MMP9 | |
| SCHEMBL2361594 | 0.74 | LMNA (0.49) | ALDH1A1SMN1; SMN2HPGDMMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627630-A1 | SEROTONIN REUPTAKE INHIBITORS | Theravance, Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051103-A1 | SEROTONIN REUPTAKE INHIBITORS | THERAVANCE, INC. (US) | 2012-04-19 | — | — | WO | disclosed |