Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 8/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22983004 | 0.81 | RAB9A (0.61) | NAMPTLMNAHIF1APOLBALDH1A1 | |
| SCHEMBL12469027 | 0.81 | SMN1; SMN2 (0.57) | LMNAPSMD14ALDH1A1NPC1RAB9A | |
| SCHEMBL30533390 | 0.80 | LMNA (0.81) | SIRT2NAMPTLMNAHIF1AALDH1A1 | |
| SCHEMBL24934252 | 0.78 | CDK8 (0.49) | ALDH1A1NPC1RAB9ATSHRMAPK1 | |
| SCHEMBL30999881 | 0.78 | ALDH1A1 (0.47) | SIRT2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL24933996 | 0.78 | ALDH1A1 (0.47) | SIRT2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL14210406 | 0.77 | SIRT2 (0.72) | SIRT2NAMPTLMNAHIF1AALDH1A1 | |
| SCHEMBL31216543 | 0.76 | KAT6A (0.44) | POLBALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL12469175 | 0.76 | ALDH1A1 (0.59) | NAMPTLMNAMCL1POLBALDH1A1 | |
| SCHEMBL31558442 | 0.75 | KEAP1 (0.55) | POLBALDH1A1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627324-A2 | SUBSTITUTED BENZAMIDES AND THEIR USES | The Board of Trustees of The Leland Stanford Junior University (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051117-A2 | SUBSTITUTED BENZAMIDES AND THEIR USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-04-19 | — | — | WO | disclosed |