Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 5/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 3/20 | 0.43 |
| ▸ | NOS1 | P29475 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SMG1 | Q96Q15 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902067 | 0.86 | MTOR (0.54) | KARS1SMG1MTORRAD52HRH3 | |
| SCHEMBL12469602 | 0.85 | HRH4 (0.45) | NOS3NOS1HTR1ADRD2HTR2A | |
| SCHEMBL902015 | 0.81 | ITGB2 (0.46) | KARS1SMG1MTOR | |
| SCHEMBL901638 | 0.80 | PRKD3 (0.43) | KARS1NOS3NOS1SMG1MTOR | |
| SCHEMBL24322998 | 0.77 | HRH3 (0.56) | RAD52HRH3 | |
| SCHEMBL1704599 | 0.76 | CKS1B (0.51) | KIT | |
| SCHEMBL4180910 | 0.76 | GAA (0.51) | HTR1ADRD2HTR2ARAD52HRH3 | |
| SCHEMBL6921614 | 0.74 | CDK1 (0.43) | KARS1PIK3C3SMG1RAD52CDK1 | |
| SCHEMBL15345047 | 0.71 | DRD4 (0.50) | DRD2RAD52HRH3 | |
| SCHEMBL23901371 | 0.71 | MTOR (0.52) | KARS1SMG1MTORRAD52HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |