Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
| ▸ | KARS1 | Q15046 | 4/20 | 0.42 |
| ▸ | SMG1 | Q96Q15 | 4/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902015 | 0.89 | ITGB2 (0.46) | PRKD3PRKD1PRKD2KARS1SMG1 | |
| SCHEMBL1704599 | 0.84 | CKS1B (0.51) | — | |
| SCHEMBL901785 | 0.83 | KARS1 (0.53) | PRKD1PRKD2KARS1SMG1MTOR | |
| SCHEMBL902067 | 0.83 | MTOR (0.54) | KARS1SMG1MTORKDM4EL3MBTL1 | |
| SCHEMBL901843 | 0.81 | ASIC3 (0.46) | NOS3NOS1MAPK1LMNATSHR | |
| SCHEMBL1579600 | 0.80 | CNR1 (0.47) | CNR1MAPK1LMNATSHRALDH1A1 | |
| SCHEMBL12469600 | 0.80 | KARS1 (0.45) | KARS1SMG1MTORNOS3NOS1 | |
| SCHEMBL3442387 | 0.79 | ALDH1A1 (0.56) | MAPK1LMNATSHRALDH1A1KDM4E | |
| SCHEMBL1704662 | 0.78 | KARS1 (0.72) | KARS1SMG1CDK1CDK2LMNA | |
| SCHEMBL902071 | 0.78 | KARS1 (0.72) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |