Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 5/20 | 0.46 |
| ▸ | ITGAL | P20701 | 5/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901638 | 0.89 | PRKD3 (0.43) | KARS1MTORSMG1PRKD3PRKD1 | |
| SCHEMBL902018 | 0.86 | NCF1 (0.52) | CKS1BSKP1SKP2NCF1PIK3CA | |
| SCHEMBL1704599 | 0.85 | CKS1B (0.51) | CKS1BSKP1SKP2PIK3CAMAP4K4 | |
| SCHEMBL902067 | 0.84 | MTOR (0.54) | KARS1MTORSMG1 | |
| SCHEMBL12469600 | 0.81 | KARS1 (0.45) | KARS1MTORSMG1 | |
| SCHEMBL29239202 | 0.81 | LRRK2 (0.50) | ITGB2ITGALICAM1PTGDR2CKS1B | |
| SCHEMBL30928278 | 0.81 | LRRK2 (0.50) | ITGB2ITGALICAM1PTGDR2CKS1B | |
| SCHEMBL1704697 | 0.78 | KARS1 (0.71) | KARS1 | |
| SCHEMBL9932291 | 0.74 | MEN1 (0.48) | ITGB2ITGALICAM1PTGDR2CKS1B | |
| SCHEMBL901785 | 0.74 | KARS1 (0.53) | KARS1MTORSMG1PRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |